SRY as a potential therapeutic target for men with Parkinson’s Disease
Objective: Develop a potential disease-modifying gene therapy for men with Parkinson’s Disease Background: A hallmark symptom of PD is the loss of midbrain dopamine (DA)…HYPERSEXUAL DISORDER IN GBA-ASSOCIATED PARKINSON’S DISEASE: CASE REPORT
Objective: To describe a patient with PD and hypersexual disorder carrying a GBA variant. Background: Compulsive sexual behavior occurs in 4% of patients with Parkinson’s…Mutations in GBA and LRRK2 are not associated with increased inflammatory markers
Objective: To assess central and peripheral cytokines among Parkinson's disease (PD) patients with mutations in the LRRK2 and GBA genes as well as among non-manifesting…Molecular investigation of apparently healthy heterozygous Parkin mutation carriers
Objective: To investigate whether apparently healthy individuals carrying a heterozygous pathogenic Parkin (PRKN) mutation show molecular phenotypes of mitochondrial dysfunction. Background: Homozygous or compound-heterozygous mutations…CSF MicroRNA Analysis Reveals Angiogenesis And Autophagy Defects In Parkinson’s DiseasePatients
Objective: We investigated the effects of discoidin domain receptor (DDR)-1 inhibition on CSF miRNAs in Parkinson’s disease patients. Background: MicroRNAs (miRNAs) are post-transcriptional regulators of…Motor cerebro-cerebellar networks breakdown among different subtypes of Parkinson’s disease
Objective: The aim of this study was to investigate functional alterations within motor circuits of the cerebro-cerebellar system in tremor-dominant (TD) and postural instability and…Compensatory functional mechanisms of response inhibition in Parkinson’s Disease with impulse control disorders
Objective: To investigate response inhibition in Parkinson’s disease (PD) patients with impulse control disorders. Specifically, the neural underpinnings of two aspects of inhibition: proactive inhibition…The evaluation of the swallow tail sign in patients with parkinsonism or gait disorders
Objective: The goal of the study is to evaluate the reliability of swallow tail sign which claimed to be specific for Parkinson's disease. Background: Swallow…Clinical and transcranial sonography characteristics in benign phenotype of Parkinson’s disease.
Objective: To investigate clinical and transcranial B-mode sonography (TCS) characteristics of benign phenotype of Parkinson’s disease (bPD). Background: Parkinson’s disease (PD) progression is heterogeneous. A…Regional brain iron and gene expression variation in Parkinson’s disease
Objective: To shed light on the genes underlying increased cortical iron deposition in Parkinson’s disease (PD). Background: Oxidative stress secondary to brain iron accumulation is…
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