Determination of 5-HT3 receptor levels with [3H]-GR 65630 binding in hemi-parkinsonian rats with L-DOPA induced dyskinesia
Objective: To determine the distribution of serotonin type 3 (5-HT3) receptors in brain areas implicated in L-3,4-dihydroxyphenylalanine (L-DOPA) induced dyskinesia in the 6-hydroxydopamine (6-OHDA)-lesioned rat…Biomarker candidates – Peptides identified to be differentially abundant in cerebrospinal fluid of patients with Parkinson´s disease
Objective: The aim of this study was to identify cerebrospinal fluid peptides that are differential in the cerebrospinal fluid of patients with Parkinson´s disease. Those…A direct longitudinal comparison of free water diffusion MRI and DaTscan SPECT in Parkinson’s Disease.
Objective: To compare the within-subject longitudinal sensitivity of PD biomarkers derived from DaTscan and Diffusion MRI. Background: Parkinson’s Disease (PD) is associated with impaired striatal…In-vivo cholinergic basal forebrain degeneration and cognition in Parkinson’s disease: imaging results from the COPPADIS study
Objective: To assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in a well-characterized multicentric cohort of Parkinson’s disease (PD)…Sexual divergencies in monoaminergic projections in Parkinson’s disease: a 123I-FP-CIT SPECT study
Objective: To investigate sex differences in nigrostriatal and extrastriatal 123I-FP-CIT SPECT monoaminergic projections in healthy subjects and Parkinson’s disease (PD) Background: preclinical and clinical studies suggest…Baseline and six months change in cortical perfusion in a mesenchymal stem cell trial for Parkinson’s disease
Objective: Quantify cortical perfusion at baseline and six months after a single infusion of allogeneic bone marrow-derived mesenchymal stem cells (allo-hMSC) in relation to demographic…The modification of iron accumulation in nigrosome by levodopa treatment in early Parkinson’s disease
Objective: The study was to investigate the alteration of iron accumulation in nigrosome for the early treatment of dopamine loss in PD. Background: Iron accumulation…Inter-Electrode Distance influences the phase-amplitude coupling (PAC) of Bipolar Subthalamic Local Field Potentials Recordings in Parkinson’s Disease
Objective: This study aimed to assess phase-amplitude coupling (PAC) between two local field potential (LFPs) signals captured from both wide- and close-spaced contact pairs (i.e.…Subcortical spectral perturbations during foot movements in PD patients with and without dystonia
Objective: To investigate subcortical brain oscillations at rest and during contralateral foot movements in PD patients with and without dystonia. Background: Dystonia is a painful,…PARKINSON’S DISEASE AND COVID-19 PANDEMIC: MODIFICATIONS IN MOTOR AND NON-MOTOR SYMPTOMS AND IN THE ACCESS TO MEDICAL AND NON-MEDICAL CONSULTATIONS AND TREATMENTS
Objective: The objective was to determine in a group of PD patients their perception of how isolation measures during the pandemic affected their motor and…
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