Differentiating Gait Impairments in Early Parkinson’s Disease and Early Dementia with Lewy Bodies
Objective: To characterize and differentiate gait deficits early on in individuals with DLB and PD. Background: Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD)…Subjective cognitive complaints assessed with the cognitive domain of the Non-Motor Symptoms Scale predict longitudinal cognitive trajectory in people with Parkinson’s disease with normal cognition
Objective: To investigate whether subjective cognitive complaints assessed by the Non-Motor Symptoms Scale (NMSS) are predictive of longitudinal cognitive trajectories in cognitively intact people with…Initial longitudinal analyses of objectively assessed cognitive functional abilities in a cohort with Parkinson’s disease
Objective: Detect the earliest changes in cognitively demanding activities of daily living in Parkinson's disease (PD) and determine their relationship with changes in global cognition…Systematic review of cognitive subtypes derived from data driven approaches in Parkinson’s disease
Objective: To consolidate the current literature pertaining to cognitive subtypes derived using data-driven methods in Parkinson’s Disease (PD). Background: Recent application of the Mild Cognitive…The Global Parkinson’s Genetics Program (GP2) – a year’s progress
Objective: The Global Parkinson’s Genetics Program (GP2, http://gp2.org/) aims to dramatically expand the current understanding of the genetic architecture of Parkinson’s disease (PD) and to…Methylation status of SNCA gene in multiple system atrophy and Parkinson’s disease
Objective: Parkinson’s disease (PD) and multiple system atrophy (MSA) are classical synucleinopathies caused by misfolding of alpha-synuclein protein. Clinical picture of PD and MSA in…Investigating LRRK2 and GBA genetic variability in underrepresented populations
Objective: To address the pressing need through promoting collaborative translational work evaluating genetic signatures in Latinx and African-American (AA) participants with and without Parkinson’s disease…Genotype-phenotype relations for GBA as a Parkinson’s disease risk factor gene: MDSGene Systematic Review
Objective: To provide a comprehensive and systematic review of genotype-phenotype associations of GBA variants for Parkinson’s disease (PD). Background: Biallelic pathogenic variants in the glucocerebrosidase gene (GBA) cause Gaucher disease (GD).…Rapamycin attenuates nigral and hippocampal alpha-synuclein accumulation in AAV-mediated alpha-synuclein overexpression model of Parkinson’s disease
Objective: To examine the possible neurorestorative effects of chronic rapamycin treatment in AAV-mediated alpha-synuclein (a-syn) overexpression model of Parkinson’s disease (PD), designed to induce hippocampal…VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease
Objective: To establish the pathogenic effects of the PD-causing VPS35 D620N mutation in vivo and address possible underlying mechanisms. Background: D620N mutation in the vacuolar…
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