Blood-based circulating microRNAs for discriminating between Parkinson’s disease subtypes
Objective: The aim of this study was to establish candidate blood miRNAs biomarkers for PD by comparing differences in miRNAs expression between distinct PD subtypes. Background: Blood…LIPAD (LRRK2/Luebeck) International Parkinson’s Disease Study: Protocol and feasibility study
Objective: To systematically assess clinical signs and symptoms including non-motor features, comorbidities, medication and environmental factors in 1,000 participants internationally: 300 with LRRK2 (Leucine-rich repeat…Fatty acids and Glucocerebrosidase activity as potential biomarkers of stearyl-CoA desaturase inhibition; an observational study of inter and intraday variation in healthy volunteers and patients with Parkinson’s disease
Objective: This study aimed to assess the naturally occurring levels and variation in plasma fatty acids (FA) and ceramide metabolism in healthy volunteers (HV) and…PD phenotype with premotor RBD is associated with a dysbiotic profile of gut microbiota.
Objective: The aim of the study was to compare the fecal microbial composition of a group of PD patients with and without premotor RBD. Background:…Longitudinal change in thalamic white matter macrostructure and volume in Parkinson’s disease depression
Objective: To investigate thalamic subnuclei volume and macrostructural white matter changes in Parkinson’s disease (PD) depression. Background: Depression is the most common neuropsychiatric feature of…Dynamic functional connectivity changes in Parkinson’s disease patients with REM sleep behavior disorder
Objective: Our aim was to explore dynamic network connection changes in PD patients with RBD. Background: Rapid eye movement (REM) sleep behavior disorder (RBD) is…Association of presynaptic dopaminergic denervation with therapeutic effects of globus pallidus deep brain stimulation on freezing of gait in advanced Parkinson’s disease
Objective: To investigate the association of presynaptic dopaminergic denervation with the therapeutic effect of globus pallidus (GPi) DBS in advanced PD patients with FOG. Background:…Reduced cerebral energy metabolism in Parkinson’s disease in contrast to Progressive Supranuclear Palsy
Objective: To determine the significance of 31P-MRSI to differentiate between idiopathic Parkinson’s disease (PD), Progressive supranuclear palsy (PSP), and healthy control subjects. Background: Bioenergetic disturbances,…VMAT2 availability in Parkinson’s Disease with Rapid Eye Movement Sleep Behaviour Disorder
Objective: To use [11C]DTBZ PET imaging to explore vesicular monoamine transporter 2 (VMAT2) availability in Parkinson’s disease (PD) with and without rapid eye movement sleep…Increased free-water in the substantia nigra in idiopathic REM sleep behaviour disorder
Objective: In this study, we tested the hypothesis that free water is elevated in the posterior substantia nigra of idiopathic rapid eye movement sleep behaviour…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.