Machine Learning (ML) Prediction of Parkinson’s Disease (PD) Risk and Nigral Neuron Density
Objective: To investigate associations between nigral neuron density and ML-based PD risk prediction. Background: Early identification of persons at high risk for developing PD is…Non-Tremor Motor Dysfunction is Associated with AD Biomarkers in Lewy Body Dementias
Objective: To investigate the clinical influence of Alzheimer’s disease (AD) co-pathology on motor features in Lewy Body Dementia (LBD). Background: There is considerable heterogeneity of…Cognitive reserve in non-demented patients with Parkinson’s disease might protect against amyloid burden effect on cognition
Objective: To evaluate the effect of cognitive reserve (CR) in patients with Parkinson’s disease (PD) without dementia. Background: CR concept is a principal factor explaining…Dissociable contribution of serum NfL and p-tau181 to cognitive impairment and mild cognitive impairment in Parkinson’s disease.
Objective: To analyze the contribution of serum NfL and p-tau181 levels to cognitive impairment and mild cognitive impairment (PD-MCI) in non-demented PD patients. Background: Autopsy…Parkinson’s Disease, Cognitive Function and Medication Management: A Problem in Routine Care
Objective: Explore the relationship between objective and patient-reported assessment of cognition to patient-reported medication management capabilities. Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder…Rare UQCRC1 variants in Chinese patients with Early Onset Parkinson’s Disease
Objective: To screen the variants of UQCRC1 in Chinese patients with early onset PD (EOPD). Background: Mitochondrial ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) gene…Familial Parkinson’s disease (PD) with anticipation phenomenon. Undescribed variant in the LRRK2 gene (c.4001G> A (p.Arg1334Gln))
Objective: We describe a family with 4 members affected by PD, carrying a new variant of the LRRK2 gen, with anticipation phenomenon in succeding generation.…Reduced serum PRDX3 levels are a biomarker for Asian LRRK2 carriers in Parkinson’s disease
Objective: We measured serum peroxiredoxin-3 (PRDX3) levels in Parkinson’s disease (PD) patients with and without LRRK2 risk variants, hypothesizing that PD LRRK2 carriers will show…The role of amylin in Parkinson´s disease neurodegenerative process
Objective: We investigate the functional interaction between two amyloidogenic (amylin and synuclein) proteins as a potential mechanism for neurodegeneration in Parkinson disease (PD). Background: PD…Close relationship between CSF lipidomic alterations and cognitive decline in Parkinson’s disease.
Objective: To clarify what the lipidome of biological samples reflects in the pathology of Parkinson’s disease (PD). Background: The lipid pattern in the cerebrospinal fluid…
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