Cerebrospinal fluid levels of oxidative stress measured using diacron-reactive oxygen metabolites and biological antioxidant potential in patients with Parkinson’s disease and progressive supranuclear palsy
Objective: We aimed to evaluate cerebrospinal fluid (CSF) levels of oxidative stress (OS) and antioxidant potential using diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential…Markers of Parkinson-related impulsive-compulsive behaviors in the activity of single units in the subthalamic nucleus
Objective: To characterize the features of the activity of single neurons of the subthalamic nucleus associated to impulsive-compulsive behaviors (ICBs) in Parkinson’s Disease (PD). Background:…Cellular Modeling of Tyrosine Hydroxylase Deficiency Recapitulates Patient Phenotypes and Response to Treatment.
Objective: Characterize a new cellular model of Tyrosine Hydroxylase deficiency (THD) based on induced pluripotent stem cells (iPSCs) to better understand the pathophysiology and test…Medication effects and validity of home-based freezing tests in Parkinson’s disease
Objective: Determine the validity of a ‘freezing-provoking protocol’ (FOG-PP) in the home setting and assess the effects of medication on freezing of gait (FOG) during…FEASIBILITY OF THE HOME-BASED DANCE EXERCISE FOR ADULTS WITH MODERATE PARKINSON’S DISEASE – A PILOT STUDY CASE REPORT
Objective: To explore the feasibility of a home-based dance exercise for adults with moderate Parkinson’s Disease (PD) on balance, functional mobility, quality of life (QOL),…Exercise habits of People with Parkinson’s across different ethnic populations
Objective: To investigate exercise habits across different ethnicities of People with Parkinson’s. Background: There is evidence that exercise is beneficial for People with Parkinson’s (PwP)…Development of a remote physical exercise program during COVID-19 pandemic for individuals with Parkinson’s disease
Objective: To describe the development process of adaptation of in-person physical exercise program to telemonitoring format to people with Parkinson’s disease (PD). Background: People with…‘In It Together’: including carers to improve outcomes for people with Parkinson’s
Objective: Informal carers of people with Parkinson’s (PwP) can undertake multiple roles, including personal, emotional, financial, or household tasks [1] increasing as the condition progresses.…Impact of ALXN1840 on the neurological symptoms of Wilson disease: secondary outcomes of a phase 2, open-label, single-arm study
Objective: To evaluate neurological efficacy outcomes of ALXN1840 treatment in adults with Wilson disease (WD) from a phase 2, open-label, single-arm study (NCT02273596). Background: WD…Does MDS-UPDRS provide greater sensitivity to mild disease than UPDRS for assessing motor severity in early Parkinson’s disease?
Objective: To test whether The Movement Disorder Society revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III (Motor Examination) items provide increased sensitivity…
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