Auxilin knockout mice: a model for Parkinsonism with dopamine dysregulation and synucleinopathy
Objective: To evaluate the role of auxilin in the pathogenesis of Parkinson’s disease (PD). Background: Auxilin or DNAJC6, a brain-specific co-chaperone plays central role in…Is it time to consider circulating microRNAs as a diagnostic biomarker in REM sleep behavior disorder?
Objective: To detect the expression of two circulating microRNAs (miRNAs) in patients with REM sleep behavior disorder (RBD) compared to patients with Parkinson´s Disease (PD).…Spatiotemporal Changes in Substantia Nigra Neuromelanin Content from Prodromal to Clinical Parkinson’s Disease
Objective: To investigate the voxel-wise spatiotemporal changes in neuromelanin-sensitive MRI (NM-MRI) signal in the substantia nigra and their relation to clinical scores of disease severity…Investigating Substantia Nigra Damage using Fully Automated Segmentation of Neuromelanin MRI in Early Parkinson’s Disease
Objective: Development of reliable imaging biomarkers of dopaminergic cell neurodegeneration is crucial to facilitate therapeutic drug trials in Parkinson's disease (PD). Neuromelanin-sensitive (NM) MRI techniques…Levodopa improves tremor symptom by reducing the connectivity between the thalamic subregions and postcentral gyrus in patients with Parkinson’s disease
Objective: To explore the mechanism by which levodopa modulates the functional connectivity of the subregions of the thalamus and which subregional connectivity changes are associated…Thalamic nuclei volumes and intrinsic thalamic network in motor subtype in Parkinson’s disease
Objective: The aim of this study is to investigate the alterations of thalamic nuclei volumes and intrinsic thalamic network in patients with de-novo PD according…Altered metabolic and functional resting state activity in cognitively unimpaired and impaired Parkinson’s disease patients
Objective: To assess the correspondence between functional connectivity and metabolic covariance in healthy controls and Parkinson’s disease patients (PD) with and without cognitive impairment. Background:…Diffusion Magnetic Resonance Imaging with Neurite Orientation and Dispersion Imaging (NODDI) Detects Early Localized Cortex Disruption in Parkinson’s Disease
Objective: To use diffusion kurtosis MRI with NODDI to assess brain cortex microstructure in Parkinson’s patients and localize disease related changes. Background: Cortical atrophy has…Predicting Longitudinal Atrophy in Parkinson’s Disease using SIR model
Objective: To predict longitudinal brain changes in Parkinson's disease (PD) using an agent-based model. Background: Considerable evidence suggests that α-synuclein(α-syn) behaves in a prion-like fashion,…An overview of vestibular function in Parkinson’s disease
Objective: To determine if people with Parkinson’s disease (PD) have greater vestibular dysfunction than age-matched healthy people (HC). Background: The vestibular system is crucial for…
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