What can tell us Non-Motor Symptoms about Cognition and Gait in the Early Stage of PD Patients
Objective: To describe the motor, cognitive and non-motor profiles in the early stage of PD using eMotion Kinect system, Moca Test and PD-CRS. Background: The…Does age at onset of Parkinson’s disease affect the development of dementia?
Objective: To investigate whether progression to dementia in senile Parkinson’s disease, SPD, (disease onset after 70 years) differs from that in old Parkinson’s disease, OPD,…Cognitive profiling of patients with neurodegenerative disorders
Objective: To characterise the cognitive decline of patients with neurodegenerative disorders: Parkinson’s disease (PD), Alzheimer's disease (AD) and essential tremor (ET) and to compare their neuropsychological…Optic atrophy and parkinsonism in a family associated with OPA1 mutation
Objective: To report a Taiwanese family with a heterozygous missense mutation of OPA1 gene (NM_130836, p.Ser582Arg) presenting with optic atrophy and parkinsonism and establish an…Characterizing the genetic architecture of Parkinson’s disease in Latinos
Objective: By performing the first genome-wide association study (GWAS) of Parkinson’s disease (PD) in Latinos, we seek to interrogate the genetic architecture of PD in…LRRK2 p.G2019S and p.N2081D variants as modifiers of glucocerebrosidase activity
Objective: To examine whether the activity of the lysosomal enzyme glucocerebrosidase (GCase) is associated with LRRK2 variants. Background: Mutations in GBA (which encodes GCase) and…GCH1 variants contribute to risk and earlier age at onset in Parkinson’s disease
Objective: Our aim was to identify the potential role of known genetic components of GCH1, including rare and common variants in coding and non-coding regions,…miRNA sequencing from routine colonic biopsies reveals an enrichment of submucosal hsa-miRNA-486-5p in Parkinson’s disease
Objective: In the present work, we aimed to investigate the expression of microRNAs (miRNAs) in routine colonic biopsies obtained from patients with idiopathic Parkinson's disease…Protective role of astrocytes on α-synuclein accumulation and propagation
Objective: This study is aimed to investigate the role of astrocytes on the accumulation and propagation of α-synuclein (a-syn), the main component of Lewy bodies/neurites,…Intrinsic brain functional connectivity predicts treatment-related motor complications in drug-naive Parkinson’s disease patients
Objective: Using resting-state functional MRI, we investigated intrinsic brain networks connectivity at baseline in a cohort of drug-naïve Parkinson’s disease (PD) patients which successively developed treatment-related…
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