MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • MDS Virtual Congress 2020

    The effect of Deep Brain Stimulation in patients with Parkinson’s Disease on the Brain Cognitive Functions

    A. Ivashynka, A. Cucovici (Novara, Italy)

    Objective: To evaluate the effect of Deep Brain Stimulation (DBS) on cognitive functions and affective symptoms in patients with Parkinson's Disease (PD). Background: DBS helps…
  • MDS Virtual Congress 2020

    Cerebrospinal fluid protein markers of cognition in early Parkinson’s disease

    I. Markaki, S. Bergström, P. Tsitsi, J. Remnestål, A. Månberg, E. Hertz, W. Paslawski, M. Uhlen, G. Mangone, S. Carvalho, O. Rascol, W. Meissner, E. Magnin, U. Wüllner, J.C Corvol, P. Nilsson, P. Svenningsson (Besancon, France)

    Objective: The aim of this multicenter study was to investigate potential alterations of CSF protein levels associated with overall and domain-specific cognitive performance in early…
  • MDS Virtual Congress 2020

    Meynert Nucleus-related Cortical Thinning in Parkinson’s Disease with Mild Cognitive Impairment

    S.M Rong, Y. Li, B. Li, K. Nie, P. Zhang, TT. Cai, M.J Mei, L.J Wang, Y.H Zhang (Guangzhou, China)

    Objective: To investigate the associations between NBM/Ch4 volume and cortical thickness in PD. Background: Cognitive impairment in Parkinson’s disease (PD) involves the cholinergic system, especially the…
  • MDS Virtual Congress 2020

    Neuroprotective propensity of marmelosin against 6-OHDA-induced cognitive impairment and apoptosis via upregulation of PI3K/Akt pathway

    E. Yadav (Allahabad, India)

    Objective: Current study was designed to explore the neuroprotective effect of marmelosin against apoptosis caused by 6-hydroxydopamine (6-OHDA) by upregulating phosphoinositide 3-kinase (PI3K)/protein kinase B…
  • MDS Virtual Congress 2020

    The development and application of an adjunct genetic counseling pre-test assessment and video intervention for Parkinson’s disease (PD)

    S. Elango, V. Katsnelson, D. Raymond, S. Rodriguez, T. Lin, N. Urval, R. Ortega, S. Bressman, R. Saunders-Pullman (New York, NY, USA)

    Objective: To develop a method to improve the efficiency of genetic counseling for PD in a multiethnic cohort, with focus on development and assessment of…
  • MDS Virtual Congress 2020

    Significant hypometabolism in the posterior parietal cortex and precuneus in Parkinson’s disease with GBA mutations: [18F]FDG PET study

    C. Lee, K. Park, S. Kim, B. Lee (Seoul, Republic of Korea)

    Objective: We explored [18F]FDG PET findings of PD patients with GBA mutation. Background: Parkinson’s disease (PD) with glucocerebrosidase (GBA) mutations is characterized by early onset…
  • MDS Virtual Congress 2020

    Clinical and genetic profile of Familial Parkinson´s disease in Cali – Colombia

    J. Orozco Velez, B. Munoz Ospina, V. Quintana-Peña, J. Valderrama-Chaparro, Y. Castaño-Pino, D. Rincón, A. Navarro, I. Hernandez-Mata (Cleveland, OH, USA)

    Objective: This study aims to describe the genetic and clinical profile of 32 subjects with familial PD using NGS genetic panel and eMotion software system…
  • MDS Virtual Congress 2020

    H1/H2 MAPT Haplotype and Parkinson’s Disease in an Ashkenazi Jewish Cohort

    G. Yahalom, L. Greenbaum, S. Israeli-Korn, T. Fay-Karmon, V. Livneh, S. Hassin-Baer, Z. Gan-Or, J. Ruskey, E. Leveille, U. Rudakou, L. Krohn, G. Rouleau (Jerusalem, Israel)

    Objective: To study the Microtubule-Associated Protein Tau (MAPT) H1/H2 haplotype contribution to clinical manifestation of Parkinson’s disease (PD) in an Ashkenazi Jewish (AJ) cohort, focusing…
  • MDS Virtual Congress 2020

    Rotenone exposure is associated with mitochondrial DNA (mtDNA) damage in humans

    S. Goldman, C. Tanner, C. Gonzalez-Hunt, C. Meng, K. Comyns, M. Korell, L. Sanders (San Francisco, CA, USA)

    Objective: To determine if mtDNA damage can serve as a biomarker of prior pesticide exposure. Background: Mitochondrial dysfunction is a hallmark of PD, and exposure…
  • MDS Virtual Congress 2020

    Compartment-specific blockade of dopamine uptake in nigrostriatal pathway reveals role for nigral dopamine function in movement frequency in open-field

    M. Salvatore, E. Kasanga, K. Lanza, S. Meadows, A. Centner, C. Bishop (Fort Worth, TX, USA)

    Objective: Inhibition of tyrosine hydroxylase activity in the substantia nigra (SN) produces a significant reduction in locomotor motor activity commensurate with decreased dopamine (DA) content…
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