The effect of Deep Brain Stimulation in patients with Parkinson’s Disease on the Brain Cognitive Functions
Objective: To evaluate the effect of Deep Brain Stimulation (DBS) on cognitive functions and affective symptoms in patients with Parkinson's Disease (PD). Background: DBS helps…Cerebrospinal fluid protein markers of cognition in early Parkinson’s disease
Objective: The aim of this multicenter study was to investigate potential alterations of CSF protein levels associated with overall and domain-specific cognitive performance in early…Meynert Nucleus-related Cortical Thinning in Parkinson’s Disease with Mild Cognitive Impairment
Objective: To investigate the associations between NBM/Ch4 volume and cortical thickness in PD. Background: Cognitive impairment in Parkinson’s disease (PD) involves the cholinergic system, especially the…Neuroprotective propensity of marmelosin against 6-OHDA-induced cognitive impairment and apoptosis via upregulation of PI3K/Akt pathway
Objective: Current study was designed to explore the neuroprotective effect of marmelosin against apoptosis caused by 6-hydroxydopamine (6-OHDA) by upregulating phosphoinositide 3-kinase (PI3K)/protein kinase B…The development and application of an adjunct genetic counseling pre-test assessment and video intervention for Parkinson’s disease (PD)
Objective: To develop a method to improve the efficiency of genetic counseling for PD in a multiethnic cohort, with focus on development and assessment of…Significant hypometabolism in the posterior parietal cortex and precuneus in Parkinson’s disease with GBA mutations: [18F]FDG PET study
Objective: We explored [18F]FDG PET findings of PD patients with GBA mutation. Background: Parkinson’s disease (PD) with glucocerebrosidase (GBA) mutations is characterized by early onset…Clinical and genetic profile of Familial Parkinson´s disease in Cali – Colombia
Objective: This study aims to describe the genetic and clinical profile of 32 subjects with familial PD using NGS genetic panel and eMotion software system…H1/H2 MAPT Haplotype and Parkinson’s Disease in an Ashkenazi Jewish Cohort
Objective: To study the Microtubule-Associated Protein Tau (MAPT) H1/H2 haplotype contribution to clinical manifestation of Parkinson’s disease (PD) in an Ashkenazi Jewish (AJ) cohort, focusing…Rotenone exposure is associated with mitochondrial DNA (mtDNA) damage in humans
Objective: To determine if mtDNA damage can serve as a biomarker of prior pesticide exposure. Background: Mitochondrial dysfunction is a hallmark of PD, and exposure…Compartment-specific blockade of dopamine uptake in nigrostriatal pathway reveals role for nigral dopamine function in movement frequency in open-field
Objective: Inhibition of tyrosine hydroxylase activity in the substantia nigra (SN) produces a significant reduction in locomotor motor activity commensurate with decreased dopamine (DA) content…
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