The feasibility of cognitive telerehabilitation in patients with Parkinson´s disease: The pilot data
Objective: The aim of this study was to focus on the feasibility and potential benefits of cognitive telerehabilitation (CTR) in patients with Parkinson´s disease (PD).…The relationship between neuromelanin-sensitive MRI, [123I] meta-iodobenzylguanidine scintigraphy and cognition, in patients with Parkinson’s disease
Objective: We investigate the relationship between the contrast ratio of locus coeruleus (LC-CR) in neuromelanin-sensitive MRI(NMI), MIBG scintigraphy, and cognition/hallucination, in patients with Parkinson’s disease.…An introduction to the Global Parkinson’s Genetics Program (GP2)
Objective: Expanding the current understanding of the genetic architecture of Parkinson’s disease (PD), accelerate discovery and validation of novel disease-causing genetic mutations and provide training…Apolipoprotein E ε4 and risk of freezing of gait in early Parkinson’s disease
Objective: To investigate the association between Apolipoprotein E (APOE) genotype and freezing of gait (FOG) in Parkinson’s disease (PD). Background: This cohort study using the…A novel likely pathogenic SNCA variant associated with Parkinson’s disease
Objective: To report a novel SNCA likely pathogenic variant. Background: The A53T mutation in the SNCA gene, encoding alpha-synuclein (a-syn), was the first established genetic…LIPAD (LRRK2/Luebeck) International Parkinson’s Disease Study: Detecting genetic and environmental modifiers of penetrance and disease expression
Objective: The international multicenter LIPAD study is a deep-phenotyping, follow-up study to ROPAD (Rostock Parkinson’s Disease Study) with the aim to systematically characterize Parkinson's disease…Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons
Objective: To unravel the existence of stealth polymorphs of α-synuclein. Background: The conformational strain diversity characterizing α-synuclein (α-syn) amyloid fibrils is possibly at the origin of the…Red blood cells alpha-synuclein heteroaggregates in the differential diagnosis of Lewy body dementias, Alzheimer’s disease and healthy controls
Objective: To investigate the diagnostic value of red blood cells (RBC) levels of total alpha-synuclein (α-syn), beta-amyloid (Aβ) 1-42, tau and its heteroaggregates in Lewy…Body weight and brainstem raphe echogenicity in patients with Parkinson’s disease
Objective: We aimed to investigate and compare of body weight between normal and abnormal BR echogenicity in patients with PD. Background: Weight loss is frequent…Automatic Detection of Nigrosome Degeneration in Susceptibility-Weighted MRI for Computer-Aided Diagnosis of Parkinson’s Disease Using Machine Learning
Objective: Automatize the detection of ‘swallow-tail’ appearance in substantia nigra dopaminergic neurons using MRI for more robust tests on Parkinson’s disease (PD) diagnosis. Background: Differential…
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