Clinical and Genetic Characteristics of the University of Pennsylvania Parkinson’s Disease Population: Results from the Molecular Integration in Neurological Diagnosis (MIND) Initiative
Objective: To describe the clinical characteristics and the frequency of GBA and LRRK2 variants in the Parkinson’s disease (PD) patient population at The University of…Non-motor network decoupling accompanies conversion to freezing of gait in Parkinson’s disease
Objective: To investigate the resting state connectivity in cortico-striatal-thalamo-cortical networks pre-conversion and pre- to post-conversion to Freezing of Gait in Parkinson’s disease. Background: Freezing of…Elevated nigral iron is associated with low plasma serotonin in Parkinson’s disease
Objective: The objective of this work was to determine whether plasma serotonin levels in Parkinson’s disease (PD) are related to iron levels in the brain,…Graph theory analysis of dopamine D2 receptor network in Parkinson’s disease patients
Objective: The aim of this study was to explore a novel method of analyzing positron emission tomography (PET) data using graph theory analysis. To this…Functional connectivity of the basal ganglia in tremor dominant and non-tremor dominant Parkinson’s disease
Objective: To explore differences in functional connectivity of the basal ganglia in tremor dominant and non-tremor dominant Parkinson’s disease (PD) using seed-to-voxel based resting state…Abnormal network interconnections dynamics correlate with levodopa-induced dyskinesia in Parkinson’s disease
Objective: To explore the pathogenesis of dyskinesia, the present study was conducted to investigate that how large-scale functional network interactions change dynamically in the temporal…Progression of cortical thinning in Parkinson’s disease
Objective: We sought to validate cortical thickness as an objective biomarker of Parkinson’s disease (PD) progression. Background: Cortical thickness analysis has been proposed as a…Asymmetrical cochlear dysfunction as a lateralized non-motor feature in Parkinson’s disease
Objective: We evaluated hearing function in a population of PD patients to investigate: 1) the occurrence of hearing loss; 2) the possible lateralization of hearing…Wearable sensors- early prediction of freezing of gait episodes based on bilateral leg stepping coherence in patients with Parkinson’s disease
Objective: To evaluate the characteristics of a freezing of gait (FOG) detection algorithm based on continuous data from inertial sensors (placed bilaterally on the shanks…Excessive Daytime Sleepiness in Parkinson’s disease and Narcolepsy Genetic Risk Allele HLA DQB1*0602
Objective: To determine whether narcolepsy risk allele HLA DQB1*0602 is associated with excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD) on dopaminergic agents.…
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