Alpha-synuclein preformed fibril (PFF)-triggered synucleinopathy recapitulates neurochemical features of human PD: A PET study in rats
Objective: To investigate longitudinal dopaminergic deficits and similarity to human Parkinson’s disease (PD) using PET imaging in the rat alpha-synuclein (a-syn) preformed fibril (PFF) model.…In vivo markers of anxiety in drug-naïve Parkinson’s disease
Objective: To investigate imaging and CSF markers of disease pathology associated with anxiety in drug-naïve idiopathic Parkinson’s disease (PD) patients. Background: Anxiety is a frequent…Rate of Neuromuscular Excitation during Cycling Related to Mobility in Parkinson’s Disease
Objective: Aim 1 was to compare rates of neuromuscular excitation during cycling at maximum pedaling speeds between people with Parkinson’s disease (PD) who are fast…Somatosensory temporal discrimination threshold improves after unilateral HIFU subthalamotomy in asymmetrical PD
Objective: To compare somatosensory temporal discrimination threshold (STDT) in both body sides previously and 4 months after unilateral high intensity focused ultrasound (HIFU) subthalamotomy of…The role of dopamine mis-metabolism in preclinical Parkinson’s disease olfactory deficits
Objective: To gain an understanding of the underlying pathological mechanisms of Parkinson’s disease (PD)-related hyposmia using post-mortem human olfactory bulbs and an in vivo model…Serum molecular markers and non-motor symptoms in Parkinson’s disease
Objective: The aim of this study was to examine the association between several serum molecular markers and different measures of non-motor symptom burden in PD.…Poor Sleep Quality is Associated With Fatigue in Early Parkinson’s Disease: A Longitudinal Study in the Early Parkinson’s Disease Longitudinal Singapore Study (PALS) Cohort
Objective: This study aims to explore the associations between baseline sleep quality and the progression of other non-motor symptoms in early Parkinson’s disease (PD). Background:…Trajectories of pain in newly diagnosed Parkinson’s disease
Objective: To determine the frequency and stability of pain over time in a cohort of patients with early Parkinson’s disease (PD). Background: Pain is a…Frequency of Wearing-Off Symptoms in Parkinson’s disease Fluctuators: An on/off evaluation
Objective: To determine if the frequency of wearing-off symptoms in Parkinson’s disease (PD) patients who report fluctuations differs from patients without fluctuations. Background: Wearing-off, the…Difference in olfactory impairment between tremor dominant and akinetic rigid dominant Parkinson’s disease patients
Objective: To investigate difference in olfactory impairment between tremor dominant (TD) and akinetic rigid dominant (ARD) Parkinson’s disease patients. Background: PD can be classified in…
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