Development and Characterization of an Ultrasensitive Assay Platform for Detection of PD Associated alpha-Synuclein Oligomers in Human Blood
Objective: To develop a sensitive, specific and consistent detection of a-SynO in biofluids to provide a reliable biomarker for disease diagnosis, progression, and a theranostic…Can clinical outputs predict BDNF levels in people with Parkinson’s disease?
Objective: To modelling the relationship between Brain-Derived Neurotrophic Factor (BDNF) levels and clinical variables (stages of disease and cognition) in people with Parkinson's disease (PD).…Alexithymia, Depression, and Cognition in Patients with Parkinson’s disease
Objective: The aim of our study is to examine the relation of alexithymia with cognition and depression in non-demented patients with Parkinson's disease (PD). Background:…How Parkinson’s Disease Affects Working Memory
Objective: Our study designed to (1) measure working memory via verbal Digit Span in Parkinson’s patients without mild cognitive impairment (MCI) (2) determine how dopaminergic…Gender differenes in cognitive functioning in de novo Parkinson’s disease patients
Objective: To clarify the differences in cognitive functioning across different cognitive domains, between male and female de novo PD patients. Background: Parkinson’s disease (PD) is…Diagnostic utility of cerebrospinal fluid t-tau/p-tau181 in Parkinson’s disease with mild cognitive impairment: A cross-sectional study in Chinese cohort
Objective: This study explores the value of α-Syn, Aβ1-42, t-tau, p-tau181 in cerebrospinal fluid(CSF) and their ratios for the diagnosis of Parkinson's disease with mild…First clinical and genetic analysis of LRRK2 G2019S, R1441G/C/H/, I2020T and Y1699C mutations in Costa Rican patients with Parkinson’s disease
Objective: To assess the frequency of G2019S, R1441G/C/H, I2020T and Y1699C mutations in a Costa Rican cohort of Parkinson’s disease (PD) cases and controls. Background:…Whole-exome sequencing in early-onset Parkinson’s disease among ethnic Chinese
Objective: The objectives of this study were to assess the genetic and clinical features of early-onset Parkinson’s disease (EOPD) among ethnic Chinese from mainland China.…The First-Ever CNV Analysis in Latin American Parkinson’s Disease Patients
Objective: To assess the CNV burden in a cohort of Latin American Parkinson’s disease (PD) patients and controls. Background: Despite the fact that PD prevalence…ADAM10 polymorphisms are not associated with susceptibility to Parkinson’s disease and Parkinson’s disease with cognitive impairment in a Chinese cohort
Objective: This study is to explore the relationship between the rs442495 and rs593742 loci of ADAM10 gene and Parkinson's disease( PD) or PD cognitive impairment.…
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