New compound increasing glucocerebrosidase activity on primary cell cultures obtained from patients with GBA-associated Parkinson’s disease
Objective: To determine whether new chemical modifications of the previously described allosteric GCase chaperone N607 (Aflaki E et.al Neurosc. 2016) increase GCase activity in monocyte-derived…High levodopa plasma concentration in the acute levodopa challenge test predicts levodopa-induced dyskinesia in Parkinson’s disease
Objective: We aimed to investigate the correlation between levodopa pharmacokinetics and levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD). Background: In patients with PD, pulsatile dopaminergic…Sensor-Based Gait Measurements Predict Subthalamic Deep Brain Stimulation Frequency in Parkinson’s Disease Patients – A Proof of Concept Study
Objective: To conduct a proof-of-concept study to demonstrate that objectively measured gait kinematics can predict the choice of subthalamic nucleus deep brain stimulation (STN-DBS) frequency…Electrochemical skin conductance as a marker of autonomic failure in patients with Multiple System Atrophy
Objective: We investigated the interest of a quick and non-invasive assessment of sweating as a marker of autonomic failure (AF) in Multiple System Atrohpy (MSA).…Midbrain/pons area ratio and clinical features predict the prognosis of Progressive Supranuclear Palsy
Objective: This retrospective study aims to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of…Vascular Parkinsonism (VP) score: A clinical scoring system to differentiate between vascular from degenerative parkinsonism
Objective: To establish a clinical scoring system to differentiate between vascualar from degenerative parkinsonism. Background: Vascular parkinsonism (VP) constitutes (5-8) % of all parkinsonian disorders.…Long and short survival in Parkinson syndrome: pathology and genetics are key prognostic factors
Objective: To study the clinical, pathological and genetic profile of Parkinson syndrome (PS) cases that have > 20 years survival (long survival, or LS) compared…Visuospatial training improved the visuospatial abilities in child with cerebral palsy: case report
Objective: The goal of this study was to assess the impact of 16 weeks of visuospatial training on the visuospatial abilities in 6 years of…Painful Legs and Moving Toes (PLMT): A Case Series
Objective: Describe and characterize our PLMT patients in terms of clinical presentation, neurophysiology, imaging, associated conditions and response to treatment. Background: First described by Spillane…Challenge Point Guide: Characterizing exercises performed in multilevel Parkinson-specific community exercise classes
Objective: To present a guide that characterizes the safest and most challenging motor and cognitive exercises performed in our multilevel Parkinson-specific community exercise classes using…
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