Identification of Parkinson’s disease predisposition genes in high-risk pedigrees
Objective: To identify families with an increased risk of Parkinson’s disease (PD) and the gene variants associated with such increased disease risk studying large multi-generation…LIPAD (LRRK2/Luebeck) International Parkinson’s Disease Study: Detecting genetic and environmental modifiers of penetrance and disease expression
Objective: The international multicenter LIPAD study is a deep-phenotyping, follow-up study to ROPAD (Rostock Parkinson’s Disease Study) with the aim to systematically characterize Parkinson's disease…Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons
Objective: To unravel the existence of stealth polymorphs of α-synuclein. Background: The conformational strain diversity characterizing α-synuclein (α-syn) amyloid fibrils is possibly at the origin of the…Red blood cells alpha-synuclein heteroaggregates in the differential diagnosis of Lewy body dementias, Alzheimer’s disease and healthy controls
Objective: To investigate the diagnostic value of red blood cells (RBC) levels of total alpha-synuclein (α-syn), beta-amyloid (Aβ) 1-42, tau and its heteroaggregates in Lewy…Body weight and brainstem raphe echogenicity in patients with Parkinson’s disease
Objective: We aimed to investigate and compare of body weight between normal and abnormal BR echogenicity in patients with PD. Background: Weight loss is frequent…Automatic Detection of Nigrosome Degeneration in Susceptibility-Weighted MRI for Computer-Aided Diagnosis of Parkinson’s Disease Using Machine Learning
Objective: Automatize the detection of ‘swallow-tail’ appearance in substantia nigra dopaminergic neurons using MRI for more robust tests on Parkinson’s disease (PD) diagnosis. Background: Differential…Association between motor symptoms and striatal VMAT2 binding in PD: a PET study
Objective: In this study, we investigate the association between motor symptoms and striatal vesicular monoamine transporter type 2 (VMAT2) binding using 18F-FP-DTBZ PET in PD…Look Again: The Diagnostic Value of Repeat Dopamine Transporter Imaging
Objective: To demonstrate value and clinical significance of repeated and longitudinal 123I-FP-CIT SPECT dopamine transporter imaging (DaTscan) with quantitative data analysis for clinical use. Background:…Impulse control disorders in Parkinson’s disease: A whole brain morphometric and diffusion tensor study
Objective: To study morphometric and structural connectivity changes in the mesocorticolimbic pathway associated with the occurrence of impulse control disorders in Parkinson's disease. Background: Impulse…Quantitative Evaluation of Iron Content in Idiopathic Rapid Eye Movement Sleep Behavior Disorder
Objective: The aim of this study was to quantitatively evaluate iron content in idiopathic rapid eye movement sleep behavior disorder patients using quantitative susceptibility mapping.…
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