Effect of P2X4 Signal Axis on Iron Metabolism in Parkinson’s Disease Animal Model
Objective: To elucidate the effect of P2X4 signal axis on iron metabolism in substantia nigra（SN）of male rats with Parkinson's disease（PD）successfully induced by 6-hydroxydopamine (6-OHDA). Background:…Intrastriatal injection of alpha-synuclein preformed fibrils results in cognitive dysfunction and L-DOPA reversible sensorimotor impairments in rats
Objective: To determine the effect of intrastriatal injection of alpha-synuclein (aSyn) preformed fibrils (PFFs) on sensorimotor and non-motor function in rats. Background: The ideal animal…Mass spectrometry-based proteomics brain analysis to distinguish between Parkinson syndromes
Objective: To address the gap existing during clinical diagnosis in differentiating among various forms of Parkinson syndrome (PS) by using mass spectrometry (MS)-based brain proteomics.…Motor network deficits during lower limb movements in Parkinson’s disease
Objective: To quantify and compare functional magnetic resonance imaging (fMRI) activity during ankle dorsiflexion in people with and without Parkinson’s disease (PD). Background: PD is…Exploring dopamine transporter single-photon emission computed tomography quantification as a measure of disease progression in idiopathic Parkinson’s disease
Objective: To evaluate the ability of DAT SPECT quantification to track disease progression in subjects with idiopathic Parkinson's disease (PD) by comparing baseline scans to…Visualization of Nigrosome 1 at 3T MRI and 18F-DOPA PET for the diagnosis of Parkinson´s disease
Objective: To determine and compare the utility of Nigrosome 1 at 3T MRI and 18F-DOPA PET for the diagnosis of Parkinson´s disease. Background: Differential diagnosis…Frailty as clinical modulator of brain damage and progression in Parkinson’s disease
Objective: To evaluate the prevalence of frailty and correlation with motor and non-motor symptoms as well as MRI atrophy and white matter hyperintensities in Parkinson's…Distinct compensatory and maladaptive wiring patterns in genotypic Parkinson’s disease
Objective: Although disease networks have been identified in Parkinson’s disease (PD) using functional imaging, it is unclear whether these represent maladaptive or compensatory responses to…Regional free-water differentially associated with glial activation, neuroinflammation, and neurodegeneration in de novo Parkinson’s disease
Objective: Assess to what extent free-water(FW) as measured by diffusion-weighted MRI(dMRI) is a neuroimaging marker of glial activation, neuroinflammation, and neurodegeneration in de novo Parkinson’s disease(PD) patients from…Deficient Balance Mechanisms during Walking in People with Parkinson’s Disease
Objective: Investigate whether people with Parkinson’s disease (PD) have deficient balance mechanisms following visual perturbations during walking. Background: We recently showed that maintaining upright balance…
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