Mov Disord Vol 35, Suppl 1 Archives - Page 143 of 149 - MDS Abstracts

MDS Virtual Congress 2020
The effect of Deep Brain Stimulation in patients with Parkinson’s Disease on the Brain Cognitive Functions
A. Ivashynka, A. Cucovici (Novara, Italy)
Objective: To evaluate the effect of Deep Brain Stimulation (DBS) on cognitive functions and affective symptoms in patients with Parkinson's Disease (PD). Background: DBS helps…
MDS Virtual Congress 2020
Cerebrospinal fluid protein markers of cognition in early Parkinson’s disease
I. Markaki, S. Bergström, P. Tsitsi, J. Remnestål, A. Månberg, E. Hertz, W. Paslawski, M. Uhlen, G. Mangone, S. Carvalho, O. Rascol, W. Meissner, E. Magnin, U. Wüllner, J.C Corvol, P. Nilsson, P. Svenningsson (Besancon, France)
Objective: The aim of this multicenter study was to investigate potential alterations of CSF protein levels associated with overall and domain-specific cognitive performance in early…
MDS Virtual Congress 2020
Meynert Nucleus-related Cortical Thinning in Parkinson’s Disease with Mild Cognitive Impairment
S.M Rong, Y. Li, B. Li, K. Nie, P. Zhang, TT. Cai, M.J Mei, L.J Wang, Y.H Zhang (Guangzhou, China)
Objective: To investigate the associations between NBM/Ch4 volume and cortical thickness in PD. Background: Cognitive impairment in Parkinson’s disease (PD) involves the cholinergic system, especially the…
MDS Virtual Congress 2020
Neuroprotective propensity of marmelosin against 6-OHDA-induced cognitive impairment and apoptosis via upregulation of PI3K/Akt pathway
E. Yadav (Allahabad, India)
Objective: Current study was designed to explore the neuroprotective effect of marmelosin against apoptosis caused by 6-hydroxydopamine (6-OHDA) by upregulating phosphoinositide 3-kinase (PI3K)/protein kinase B…
MDS Virtual Congress 2020
A large-scale full GBA1 gene screening in Parkinson’s disease in the Netherlands: 18 novel and 1 ‘Dutch’ variant
J. den Heijer, V. Cullen, M. Quadri, A. Schmitz, D. Hilt, P. Lansbury, H. Berendse, W. de Berg, R. de Bie, J. Boertien, A. Boon, M. Contarino, J. van Hilten, J. Hoff, T. van Mierlo, A. Munts, A. der Plas, M. Ponsen, F. Baas, D. Majoor-Krakauer, V. Bonifati, T. van Laar, G.J Groeneveld (Leiden, Netherlands)
Objective: Assess the entire GBA1 gene in Parkinson’s disease from a single large population. Background: The commonest genetic risk factor for Parkinson’s disease known to…
MDS Virtual Congress 2020
Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease
J. Lee, P. Pinares-Garcia, H. Loke, S. Ham, E. Vilain, V. Harley (Clayton, Australia)
Objective: Given the presence and function of SRY in male DA (dopamine) neurons, we hypothesised that dysregulation of SRY may contribute to male susceptibility to…
MDS Virtual Congress 2020
Variants in the saposin D domain of prosaposin gene are linked to Parkinson’s disease
Y. Oji, T. Hatano, S. Ueno, M. Funayama, K. Ishikawa, A. Okuzumi, S. Noda, S. Sato, W. Satake, T. Toda, Y. Li, T. Hino-Takai, S. Kakuta, T. Tsunemi, H. Yoshino, K. Nishioka, T. Hattori, Y. Mizutani, T. Mutoh, F. Yokochi, Y. Ichinose, K. Koh, K. Shindo, Y. Takiyama, T. Hamaguchi, M. Yamada, M. Farrer, Y. Uchiyama, W. Akamatsu, J. Matsuda, Y. Wu, N. Hattori (Tokyo, Japan)
Objective: To investigate whether the variants of prosaposin can be linked to Parkinson's disease (PD) [1]. Background: Recent growing investigations have promoted the evidence of…
MDS Virtual Congress 2020
Effect of P2X4 Signal Axis on Iron Metabolism in Parkinson’s Disease Animal Model
A. Xie, J. Gao, J. Ma (Qingdao, China)
Objective: To elucidate the effect of P2X4 signal axis on iron metabolism in substantia nigra（SN）of male rats with Parkinson's disease（PD）successfully induced by 6-hydroxydopamine (6-OHDA). Background:…
MDS Virtual Congress 2020
Intrastriatal injection of alpha-synuclein preformed fibrils results in cognitive dysfunction and L-DOPA reversible sensorimotor impairments in rats
S. Fleming, J. Patterson, L. Yan, C. Kemp, K. Miller, A. Stoll, M. Duffy, D. Herman, J. Lipton, K. Luk, J. Goudreau, C. Sortwell (Rootstown, OH, USA)
Objective: To determine the effect of intrastriatal injection of alpha-synuclein (aSyn) preformed fibrils (PFFs) on sensorimotor and non-motor function in rats. Background: The ideal animal…
MDS Virtual Congress 2020
Mass spectrometry-based proteomics brain analysis to distinguish between Parkinson syndromes
A. Rajput, P. Chumala, B. Thompson, A. Rajput, G. Katselis (Saskatoon, SK, Canada)
Objective: To address the gap existing during clinical diagnosis in differentiating among various forms of Parkinson syndrome (PS) by using mass spectrometry (MS)-based brain proteomics.…