Feasibility of Studying the PD Microbiome in Frozen Saliva and Formalin-Fixed Colon From the Systemic Synuclein Sampling Study (S4)
Objective: To examine feasibility of obtaining microbiome data from frozen saliva and formalin-fixed, paraffin-embedded (FFPE) colon specimens. Background: The gastrointestinal tract microbiome is of great…Cancerous inhibitor of protein phosphatase 2A in Parkinson’s disease
Objective: To investigate the expression level of Cancerous Inhibitor of Protein phosphatase 2A (CIP2A) in Parkinson’s disease (PD), and explore the relationship between CIP2A and…Increased availability of the metabotropic glutamate receptor 5 in the motor system of patients with Parkinson’s disease
Objective: To investigate glutamatergic signaling in Parkinson’s disease (PD) compared to age- and gender-matched healthy controls by using 11C-ABP688-PET combined with MRI. Background: Increasing evidence…Noradrenergic terminal and locus coeruleus cell loss may be uncoupled in Parkinson’s disease – a PET and MRI multi-modal imaging study
Objective: To assess multimodal imaging of the noradrenergic system: magnetic resonance imaging (MRI) neuromelanin contrast of the locus coeruleus (LC) and noradrenalin transporter density with…Impulse control disorder and ventral striatum dopamine D3 receptor availability in Parkinson’s disease
Objective: To investigate the relationship between ventral striatum D3 dopamine receptor availability and severity of impulse control disorder (ICD) in Parkinson’s disease (PD). Background: Reduced…Association Between Ventricle/Brain Volumes and Mobility Metrics in Parkinson’s Disease
Objective: To investigate the relationship between brain ventricular and gray matter volumes and objective balance and gait metrics in people with Parkinson’s disease (PD). Background:…Microglial activation associated with a faster progression of nigrostriatal dysfunction in patients with isolated REM sleep behavior disorder
Objective: To assess the role of early microglial activation on the progression of nigrostriatal dysfunction, measured with 18F-DOPA PET, in isolated REM sleep behavior disorder…Neural Correlates of Semantic Fluency Deficits in Parkinson’s Disease with Mild Cognitive Impairment
Objective: To explore neural mechanisms related to semantic fluency deficits in Parkinson’s disease (PD). Background: Verbal fluency impairments are the earliest and typical cognitive deficits…Management of neuropsychiatric symptoms in Parkinson’s disease (PD) at the front door
Objective: To ascertain the number of PD patients admitted to the acute hospital with neuropsychiatric symptoms requiring a review by PD specialist, including medicine reconciliation…The Many Faces of Bradykinesia in Parkinson’s Disease : The Quantitative Analysis from A Keyboard Typing Test
Objective: To explore the characteristics of bradykinesia in PD via a keyboard typing test. Background: Bradykinesia is one of the cardinal symptoms in Parkinson’s disease…
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