Age-dependent expression of α-synuclein and its modification in non-neurodegenerative intestinal tract
Objective: To investigate the feasibility of α-synuclein(α-Syn) pathology in enteric nervous system (ENS) as a diagnostic marker for Parkinson's disease, and to clarify the distribution…A longitudinal study on alpha-synuclein in plasma neuronal exosomes as a biomarker for Parkinson’s disease development and progression
Objective: This study explored the potential use of alpha-synuclein (α-syn) in plasma neuronal exosomes as a biomarker for early Parkinson’s disease (PD) diagnosis and disease…Anxiety in Parkinson’s disease is associated with changes in the brain fear circuit
Objective: The aim of this study was to identify the anatomical and functional changes related to anxiety, especially in the “fear circuit”, by comparing PD…Attitudes of Care Partners Toward Medications for Parkinson’s Disease Psychosis
Objective: To explore attitudes regarding use of medications among care partners of individuals with Parkinson’s disease psychosis. Background: Parkinson’s disease (PD) psychosis is a highly…Donepezil for mild cognitive impairment in Parkinson’s disease: A 48-week follow-up study
Objective: To investigate the efficacy of donepezil for mild cognitive impairment (MCI) in Parkinson’s disease (PD). Background: MCI is common in PD. The mechanism of…Apomorphine Sublingual Film for On-Demand Treatment of “OFF” Episodes in Patients With Parkinson’s Disease: Impact on Impulse Control Disorders
Objective: Evaluate effect of apomorphine sublingual film (APL-130277; APL) on impulse control disorders (ICD) in patients with Parkinson’s disease (PD) and “OFF” episodes. Background: In…Long term safety of levodopa/carbidopa infusion with ND0612: Results from a phase 2b, international, open-label study
Objective: The primary objective of this long-term study was to evaluate the safety and tolerability of a 24-hour regimen and a 16-hour ‘waking day’ regimen…Interpretation of health-related quality of life outcomes from the EARLYSTIM Study
Objective: To conduct a secondary analysis of the EARLYSTIM study1 to 1: Quantify the meaning of HRQoL outcomes and 2: Evaluate the changes of disease…Real Time Quality Control for Subjective Endpoints in Clinical Trials
Objective: Here we present a system which is capable of performing nearly-real time monitoring of UPDRS part-3 motor assessments using a combination of multidimensional statistics…Dose Optimization of Apomorphine Sublingual Film for On-Demand Treatment of “OFF” Episodes in Patients with Parkinson’s Disease: Clinical and Exposure Response Findings
Objective: Evaluate if dose optimization (DO) of apomorphine sublingual film (APL-130277; APL) can achieve improved FULL “ON” response in patients with Parkinson’s disease (PD) and…
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