Disentangling postural instability-gait difficulties classification model for the prediction of cognitive impairment in de novo Parkinson’s Disease patients
Objective: To investigate whether postural instability/gait difficulties (PIGD) phenotype classification or specific PIGD-related MDS-UPDRS items may predict cognitive impairment in de novo Parkinson’s disease (PD)…GWAS on impulse control disorders in Parkinson’s disease
Objective: To identify the genetic factors associated with Impulse control disorders (ICDs) in Parkinson’s disease (PD) patients using a genome-wide approach. Background: ICDs are associated…Rare variants of the LRRK2 gene in the haplotype as one of the potential risk factors for endemic parkinsonism in a small isolated region in the Czech Republic
Objective: The aim of the study was to investigate a co-occurence of rare variants in set of genes frequently associated with parkinsonism. Background: The increased…PARK2 p.Ala82Glu variant is not associated with Parkinson’s disease
Objective: The aim of the study was to analyze potential pathogenicity of the PARK2 p.Ala82Glu mutation, by functional studies of Parkin in the mitophagy paradigm…Is early-onset of levodopa-induced dyskinesia a predictor of GBA mutation? A next-generation sequencing study of young-onset Parkinson’s disease patients in Thailand
Objective: To examine the prevalence of genetic causes in young-onset Parkinson’s disease (YOPD) patients with levodopa-induced dyskinesia (LID) in Thailand using a next-generation sequencing (NGS)…Characterization of Lewy bodies-induced neurodegeneration and synucleopathy in wild-type mice
Objective: To investigate the Lewy-body-induced degeneration and synucleopathy in wild-type mice while focusing upon origin of the Lewy bodies. Background: Neurodegenerative diseases, such as Parkinson’s…Loss of CHCHD2 and CHCHD10 disrupts mitochondrial cristae phenocopying patient mutations
Objective: Characterization of novel of a novel CHCHD2 (C2) and CHCHD10 (C10) knockout mouse model. Background: Dominant mutations in the mitochondrial paralogs CHCHD2 (C2) and…Predictors of Underlying Neurodegeneration in Drug-Induced Parkinsonism
Objective: To examine a cohort of Veterans with drug-induced parkinsonism (DIP) using [123I]Ioflupane single photon emission computed tomography (DAT-SPECT) to identify those with nigrostriatal degeneration…Inter-network connectivity dynamics underlie compensatory mechanisms in prodromal Parkinson’s disease
Objective: We aimed to investigate the dynamics of inter-network connectivity among non-manifesting GBA and LRRK2 mutation carriers. Background: The prodromal phase of Parkinson’s disease (PD)…Hyposmia as a biomarker in patients with Parkinson’s disease and atypical Parkinsonism
Objective: To investigate neural correlates associated with olfactory dysfunction using fMRI and EEG in Parkinsonism. Background: Patients with Parkinsonism experience non-motor symptoms during the onset…
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