Association of gait domains with cognitive and neuropsychiatric domains in patients with Parkinson’s disease: A Brazilian exploratory study
Objective: (i) To examine the association of gait domains (single and dual task (DT) walk) with cognitive and neuropsychiatric domains in patients with Parkinson’s disease…Clinical outcomes after DBS surgery in cognitively impaired patients with PD
Objective: To describe clinical outcomes after DBS in patients with PD and moderate cognitive impairment (CI). Background: DBS is generally contraindicated in PD patients with…Investigating Factors Contributing to Parkinson’s disease-related Cognitive Decline
Objective: The objective of this study was to identify predictive factors of cognitive decline in patients with Parkinson’s disease (PD). Background: Among those with PD,…GWAS on impulse control disorders in Parkinson’s disease
Objective: To identify the genetic factors associated with Impulse control disorders (ICDs) in Parkinson’s disease (PD) patients using a genome-wide approach. Background: ICDs are associated…Rare variants of the LRRK2 gene in the haplotype as one of the potential risk factors for endemic parkinsonism in a small isolated region in the Czech Republic
Objective: The aim of the study was to investigate a co-occurence of rare variants in set of genes frequently associated with parkinsonism. Background: The increased…PARK2 p.Ala82Glu variant is not associated with Parkinson’s disease
Objective: The aim of the study was to analyze potential pathogenicity of the PARK2 p.Ala82Glu mutation, by functional studies of Parkin in the mitophagy paradigm…Is early-onset of levodopa-induced dyskinesia a predictor of GBA mutation? A next-generation sequencing study of young-onset Parkinson’s disease patients in Thailand
Objective: To examine the prevalence of genetic causes in young-onset Parkinson’s disease (YOPD) patients with levodopa-induced dyskinesia (LID) in Thailand using a next-generation sequencing (NGS)…Characterization of Lewy bodies-induced neurodegeneration and synucleopathy in wild-type mice
Objective: To investigate the Lewy-body-induced degeneration and synucleopathy in wild-type mice while focusing upon origin of the Lewy bodies. Background: Neurodegenerative diseases, such as Parkinson’s…Loss of CHCHD2 and CHCHD10 disrupts mitochondrial cristae phenocopying patient mutations
Objective: Characterization of novel of a novel CHCHD2 (C2) and CHCHD10 (C10) knockout mouse model. Background: Dominant mutations in the mitochondrial paralogs CHCHD2 (C2) and…Predictors of Underlying Neurodegeneration in Drug-Induced Parkinsonism
Objective: To examine a cohort of Veterans with drug-induced parkinsonism (DIP) using [123I]Ioflupane single photon emission computed tomography (DAT-SPECT) to identify those with nigrostriatal degeneration…
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