Clinical outcomes after DBS surgery in cognitively impaired patients with PD
Objective: To describe clinical outcomes after DBS in patients with PD and moderate cognitive impairment (CI). Background: DBS is generally contraindicated in PD patients with…Investigating Factors Contributing to Parkinson’s disease-related Cognitive Decline
Objective: The objective of this study was to identify predictive factors of cognitive decline in patients with Parkinson’s disease (PD). Background: Among those with PD,…Blood alpha-synuclein profile and lysosomal alterations distinguish GBA1-related Parkinson’s disease from sporadic Parkinson’s disease
Objective: This study aims to characterize blood profile of alpha-synuclein and the main lysosomal proteinsas well as clinical features of PD subjects carrying GBA1 mutations…NUS1 polymorphisms modify the risk and age at onset of Parkinson’s disease
Objective: In this study, using whole-exome sequencing (WES) and direct Sanger sequencing analysis, we investigated the common and low-frequency variants of NUS1 in two case-control…Whole exome trio analysis in isolated population of southeast Moravia (Czech Republic) with familial parkinsonism suggests its heterogeneous genetic background
Objective: The aim of the study was to identify shared genetic variants potentially associated with familial neurodegenerative parkinsonism using whole-exome analysis. Background: Increased prevalence of…Genome-wide association studies of progression in Parkinson’s disease
Objective: To identify genetic variants associated with composite (cross-domain), motor, and cognitive progression in Parkinson’s disease (PD). Background: Case-control genome-wide association studies (GWASs) in PD…Male-specific exacerbation of susceptibility to α-synuclein pre-formed fibrils by developmental dieldrin exposure in mice
Objective: To determine whether developmental exposure to dieldrin exacerbates susceptibility to α-synuclein (α-syn) preformed fibril (PFF)-induced synucleinopathy in adulthood. Background: Parkinson’s disease (PD) is characterized…Feasibility of Studying the PD Microbiome in Frozen Saliva and Formalin-Fixed Colon From the Systemic Synuclein Sampling Study (S4)
Objective: To examine feasibility of obtaining microbiome data from frozen saliva and formalin-fixed, paraffin-embedded (FFPE) colon specimens. Background: The gastrointestinal tract microbiome is of great…Cancerous inhibitor of protein phosphatase 2A in Parkinson’s disease
Objective: To investigate the expression level of Cancerous Inhibitor of Protein phosphatase 2A (CIP2A) in Parkinson’s disease (PD), and explore the relationship between CIP2A and…Increased availability of the metabotropic glutamate receptor 5 in the motor system of patients with Parkinson’s disease
Objective: To investigate glutamatergic signaling in Parkinson’s disease (PD) compared to age- and gender-matched healthy controls by using 11C-ABP688-PET combined with MRI. Background: Increasing evidence…
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