First Scientific Description of the Hepato-Lenticular Degeneration
Objective: Hepato-Lenticular Degeneration (HLD) first described by German pathologist Friedrich Theodor von Frerichs in 1854, but in the West it called Wilson's Disease. In Russia…VMAT 2 inhibitor and Antipsychotic use in Individuals with Huntington’s Disease
Objective: To retrospectively investigate whether the concomitant use of VMAT2 inhibitors and antipsychotics in individuals with Huntington's disease (HD) is associated with an increased occurrence…Translatable biomarkers in gene therapy for Huntington’s Disease: learnings from pre-clinical studies
Objective: We have developed AAV5-miHTT, a recombinant AAV-based gene therapy expressing an engineered microRNA that specifically binds to HTT exon1, resulting in lowering of both…Progression of cortical thinning and neuropsychological decline in isolated Rapid Eye Movement sleep behavior disorder
Objective: We aimed to investigate the progression over time of cortical thickness and cognitive functions in isolated REM-sleep behaviour disorder (IRBD) compared to healthy controls (HC).…hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk
Objective: To demonstrate whether hUC-MSCs can benefit depressive-like behavior by altering C3/C3a-C3aR signaling to impact microglia polarization in the CUMS model. Background: Major depressive disorder (MDD) has been…MR Conditional Labeling for DBS – Basic Physics for the Non-Specialist
Objective: A non-technical overview of the physics behind MR Conditional labeling for DBS devices and the implications for diagnostic imaging. Background: MRI is the recommended…An Analysis of Health Care Utilization in Functional Movement Disorders: Does Diagnosis Make a Difference?
Objective: To investigate the impact of diagnosis on health care utilization (HCU) in the functional movement disorders (FMD) population. Background: FMD patients are considered to…Motor Fluctuations in a Real-World Sample of Patients with Parkinson’s Disease
Objective: To characterize OFF and ON times in a real-world sample of patients with Parkinson’s disease (PD) experiencing motor fluctuations (MF) with carbidopa/levodopa (CD/LD) and…Advance Care Planning in Parkinson’s Disease – Are we getting it right?
Objective: The initial aim of the study was to determine the utilisation of Advance Care Plans in people with Idiopathic Parkinson’s Disease (IPD) and Atypical…Differential impact of Lewy body disease and Alzheimer’s disease neuropathology on cognition
Objective: To examine the impact of Lewy body disease neuropathology (LBD) on domain-specific cognitive impairment in isolation and in combination with Alzheimer’s disease neuropathologic change…
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