Relationship between symptoms and regional density of metabotropic glutamate receptors subtype 1 measured with 11C-ITMM PET in de novo Parkinson’s disease
Objective: To investigate correlations of motor and non-motor symptoms with the brain densitiesof the metabotropic glutamate receptor subtype 1 (mGluR1) in de novo Parkinson’s disease…Extrastriatal dopaminergic and serotonergic pathways in Parkinson’s disease and in dementia with Lewy bodies: a 123I-FP-CIT study
Objective: To evaluate the common and divergent dopaminergic and serotonergic impairment in Parkinson's disease and dementia with Lewy bodies using 123I-FP-CIT imaging. Background: Striatal dopaminergic…Sleep Disturbances in Essential Tremor: A pilot investigation of the related brain microstructural changes using diffusion tensor imaging
Objective: In this pilot exploratory study, we aimed to search possible related brain microstructural changes of sleep disturbances (SD) in essential tremor (ET) patients. Background:…The Dutch Parkinson and Cognition study (DUPARC): Cognitive impairment and cholinergic innervation in de novo Parkinson’s Disease patients
Objective: To explore the incidence and characteristics of early cognitive impairment in Parkinson’s disease (PD) patients and the relationship with regional cholinergic innervation. Background: Cognitive…Transcranial Photobiomodulation as an adjunct to Levodopa therapy in patients with Parkinson’s Disease; an open label pilot study
Objective: To explore the effects of transcranial Photobiomodulation (tPBM) on symptoms of Parkinson's Disease and establish this therapy's efficacy as an adjunct to Levodopa. Background:…Autonomic features in E46K-SNCA carriers
Objective: To evaluate structural and functional integrity of small autonomic nerve fibers and phosphorylated alpha-synuclein (p-syn) deposition in the skin of E46K-SNCA carriers as compared…Are we underestimating the dysautonomic burden in GBA related a-synucleinopathies?
Objective: The aim of the present study is to understand the prevalence of dysautonomic symptoms in a cohort of Italian glucocerebrosidase (GBA) mutated patients with…Clinical Management of Incipient Wearing-off with the 19-Items Wearing off Questionnaire (WOQ-19)
Objective: To evaluate the use of the 19-items Wearing off Questionnaire (WOQ-19) to detect fluctuations in patients with non-advanced Parkinson's disease (PD) and to evaluate…Can we hear pathology in premanifest Huntington’s disease? Acoustic and listener-based analysis of speech
Objective: The present study evaluated the ability of acoustic and listener-based perceptual measures to differentiate speech deficits in the premanifest and early stages of HD…The Roche HD Natural History Study – an external comparator by design
Objective: The Roche Natural History (NH) study in Huntington’s disease (HD) (NCT03664804) is a prospective, longitudinal cohort study designed to provide further clinical validation of…
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