Circadian and Homeostatic Modulation of Multi-unit Activity in Dopaminergic and Striatal Structures
Objective: This study aims at investigating the impact of sleep and sleep deprivation on neuronal activity of midbrain dopaminergic areas and different subdivisions of the…Nonmotor Symptoms in Parkinson’s Disease: 36-month Follow-up Study Comparing Bilateral Subthalamic Stimulation and Standard-of-care Medication
Objective: To examine 36-month effects of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on nonmotor symptoms (NMS) and self-reported quality of life compared to…The Urge to Move in Restless Legs Syndrome Associated with Parkinson’s Disease: A Motor Impulse Control Disorder?
Objective: To determine whether there could be a semiological overlap between Restless Legs Syndrome (RLS) and Impulse Control Disorders (ICDs) in Parkinson’s Disease (PD), using…Phosphodiesterase 10A and cognition in Parkinson’s disease
Objective: We aimed to assess the associations between Phosphodiesterase 10A (PDE10A) expression in the executive striatum and cognitive performance in vivo, using [11C]IMA107 PET and…Occurrence of brain capillary dysfunction in patients with REM sleep behavior disorder
Objective: To assess whether changes in brain capillary function measured with magnetic resonance imaging (MRI) can be detected in patients with REM sleep behavior disorder…No link between striatal dopaminergic axons and dopamine transporter imaging in Parkinson’s disease
Objective: The objective of this study was to investigate if dopamine transporter (DAT) binding is associated with dopaminergic neurites in the putamen. Background: Dopamine transporter…The right hemisphere inhibitory network in patients with asymmetrical Parkinson’s disease: An fMRI study
Objective: The aim of our study was to identify the neural substrates of inhibitory processing on the stop signal task in patients with predominantly left…11C-PBB3 PET in PD: does alpha-synuclein pathology start in axonal terminals?
Objective: To use 11C-PBB3 PET binding to monitor alpha-synuclein (a-syn) pathology in PD subjects in vivo. Background: In previous work we have shown binding of…Structural connectivity changes in G2019S-LRRK2 gene mutation carriers without manifest Parkinson’s disease
Objective: We hypothesised that abnormal sprouting of serotonergic terminals in the hypothalamus may lead to abnormal structural connectivity, which can be measured with diffusion tensor…In vivo increased striatal iron deposition in Parkinson’s Disease Dementia and Dementia with Lewy Body
Objective: To evaluate iron deposition with susceptibility weighted imaging (SWI) MRI in the basal ganglia of patients affected by Parkinson’s Disease Dementia (PDD) and Dementia…
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