Therapeutic management of complicated Parkinson’s disease: clinical application of the Motor Fluctuation Indices
Objective: To evaluate the usefulness of the Motor Fluctuation Indices to assess clinically relevant change in motor fluctuations in advanced Parkinson’s disease (PD) patients after…Contribution of pedunculopontine nucleus cholinergic neurons to L-DOPA-induced dyskinesia and PD motor deficits in hemi-parkinsonian rats
Objective: To determine if chemogenetic and pharmacological modulation of pedunculopontine nucleus (PPN) cholinergic neurons can alter L-DOPA-induced dyskinesia and gait deficits in hemi-parkinsonian rats. Background:…Nutritional status in patients with Parkinson’s disease and its relationship with the motor phenotype.
Objective: To determine the nutritional status in patients with Parkinson's disease and to relate it to the motor phenotype. Background: Parkinson disease (PD) is a…Long-Term Effects of LPS and Alcohol in Rats: A Model of Neuro-Degenerative Disease
Objective: We postulate alterations of the intestinal barrier (or leaky guts) enhances inflammation, as well as the production of alpga (α)-synuclein which has characteristic pathological…Interleaving stimulation in Parkinson’s disease: interesting to whom?
Objective: Overview our patients’ experience with ILS and explore clinical scenarios in which ILS should be considered when programming DBS in PD patients. Background: Interleaving…Functional Limits of Stability and Standing Balance in people with and without Freezing of Gait
Objective: To investigate whether Freezing of Gait (FoG) impacts functional Limits of Stability (fLoS) and postural sway during quiet stance and dynamic balance in a…Skin in the game: Small fiber neuropathy in Parkinson’s disease and atypical parkinsonisms.
Objective: The aim of our study was to compare somatic and autonomic small fiber density, through skin biopsy, in Parkinson's disease (PD) and atypical parkinsonisms…Association between transfer activities and health-related quality of life in patients with Parkinson’s disease
Objective: To investigate the association between health-related quality of life (HRQoL) and transfer activities in patients with Parkinson's disease (PD). Background: Bradykinesia, rigidity, tremor and…123I-FP-CIT SPECT imaging in early PD patients versus mid and late onset PD: Longitudinal data from the PPMI study
Objective: To determine whether there are longitudinal differences in dopaminergic denervation [as exemplified by signal reduction in 123I-FP-CIT SPECT] in early PD patients versus mid…Validation of the PREDIGT Score for the Incidence Rate of Parkinson disease
Objective: To assess the discriminative power of the PREDIGT formula for incident Parkinson disease (PD). Background: The inability to predict the incidence rate of PD…
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