Memory enhancing effect of Combined Alcoholic Extract of Cedrus deodara Loud. and Vitex Nirgundi in scopolamine-induced cognitive impairment in mice
Objective: Epidemiological studies of Indian population reveal that dementia is largely a hidden problem in India. Ayurveda claims several plants are beneficial in cognitive disorders.…Utilising Magnetic Resonance Spectroscopy to investigate synucleinopathies
Objective: To study the neuronal integrity of the Anterior (ACC) and Posterior (PCC) Cingulate Cortices with Proton Magnetic Resonance Spectroscopy (H-MRS) across healthy controls (n=17),…Motor Response Inhibition – A potential tool to determine optimum STN-DBS setting
Objective: To explore the possibility of using an automated bed side test of motor response inhibition - Stop Signal Reaction Time (SSRT) while optimizing DBS…Inhibitory Repetitive Transcranial Magnetic Stimulation of Pre-Supplementary Motor Area Improves Levodopa-Induced Dyskinesia in Parkinson’s Disease
Objective: To prove the causal role of pre-supplementary motor area (preSMA) in levodopa-induced dyskinesia using an interventional brain stimulation approach that targets abnormal preSMA activity. Background:…Tau and amyloid-beta inclusions are present in pancreatic beta-cells of patients with synucleinopathies
Objective: We have assessed whether tau and amyloid beta deposits might be present in pancreatic tissue of subjects with Parkinson’s and Lewy Body dementia. Background:…Parkinson Disease Clinical Subtypes Predict Dementia and Mortality Risk
Objective: To identify PD clinical subtypes based on patterns of motor, cognitive, and psychiatric symptoms; to assess the clinical utility of each subtype in predicting…Safety and Tolerability of Apomorphine Sublingual Film During Maintenance Treatment in Patients With Parkinson’s Disease and “OFF” Episodes: A Pooled Analysis
Objective: To examine safety and tolerability of apomorphine sublingual film (APL-130277; APL) during maintenance treatment using pooled data from 4 clinical studies in patients with…Deep Brain Stimulation Wash-in/out Periods Quantified using a Palm-Worn Device to Monitor Rigidity
Objective: Characterize the temporal resurgence/amelioration of Parkinsonian rigidity corresponding to withdrawal/application of deep brain stimulation (DBS) therapy. Background: Rigidity is a cardinal symptom of Parkinson’s…A general impaired-rhythm system underpins oro-motor, manual, and gait rhythmic disturbances in Parkinson’s disease
Objective: To assess whether rhythmic disturbances in three different domains (i.e., oro-motor, finger tapping and gait domains) are related in Parkinson's disease (PD), and to…Abnormal metabolic brain network in multiple system atrophy and progressive supranuclear palsy: a replication on a new European cohort
Objective: To identify characteristic metabolic brain patterns specific for multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) in a new cohort of patients and…
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