Kick Out PD: Mobility, Quality of Life, and Feasibility Outcomes in a Pilot Study of a PD-Specific Karate Intervention
Objective: To evaluate feasibility of a community-based karate class tailored for individuals with early- to middle-stage Parkinson’s Disease (PD); to assess effect of karate on…ATP1A3 Gene Mutations Associated With Rapid-Onset Dystonia-Parkinsonism (RDP) Presenting As Functional Neurologic Disorder: A Report of Two Cases
Objective: Functional neurologic disorder (FND) diagnostic criteria continues to evolve, with current emphasis on positive neurologic signs, including sudden onset, inconsistency or incongruence, without reliance…Postural Instability Assessed by Static and Dynamic Posturography in the Early Stage of Parkinson’s Disease
Objective: The early stage of Parkinson’s disease (PD) (Hoehn-Yahr (HY) I-II stages) is characterized by a negative pull test, which clinically excludes postural instability. Previous…Paresthesia and gait impairment in a patient with advanced Parkinson disease-case report
Objective: Our main objective is to illustrate different etiologies for paresthesia and gait impairment that can occur in a patient with Parkinson disease. We present…Clinimetric properties of direct contemporaneous FOG score rating
Objective: To determine the clinimetric properties of the direct rating of the Freezing of Gait (FOG) score compared to the off-line rating from video recordings.…Homozygous Huntington’s disease with two reduced penetrance alleles: A Case Report
Objective: To clinically characterize a Huntington's disease patient with two reduced penetrance alleles. Background: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder manifesting with…Intermediate CAG repeat length in the HTT gene and comorbidity – The SHAPE Study (Swedish-Huntingtin-Alleles-and-PhenotypE)
Objective: To 1) determine the distribution of CAG repeats of the Huntingtin gene in a Swedish general population sample, 2) explore the phenotype caused by…Changes in GABAergic transmission of striatal neurons in presymptomatic Huntington’s Disease
Objective: To determine whether parameters of synaptic and extrasynaptic GABAergic inhibition of striatal projection neurons are altered in presymptomatic BACHD mice. Background: One attractive early…First-In-Human Study of LY3154207, a Dopamine D1 Receptor Positive Allosteric Modulator (D1PAM)
Objective: Evaluate the safety, tolerability, and plasma and cerebrospinal fluid (CSF) pharmacokinetics (PK) of LY3154207 (LY) following oral dosing in healthy subjects (HS). Background: LY,…Long-term safety and efficacy of rimabotulinumtoxinB in the treatment of adult sialorrhea
Objective: To assess the safety, tolerability and effectiveness of repeated rimabotulinumtoxinB injections in adults with troublesome sialorrhea over a period of 1 year. Background: Sialorrhea…
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