Mitochondrial Complex 1, Sigma 1 Receptor and Synaptic Vesicle protein 2A density in early de novo patients with Parkinson’s Disease: pilot PET data
Objective: In this study, we evaluated the density of Mitochondrial complex 1 (MC1), sigma 1 receptor (s1R) and Synaptic Vesicle protein 2A (SV2A) in early…Potential involvement of the caudate nucleus in GBA-associated Parkinson’s disease
Objective: Multimodal functional assessment of striatocortical loop integrity in Parkinson’s Disease (PD) patients with and without GBA variants Background: Biallelic GBA mutations provoke the lysosomal…Appropriateness of DAT Scan Ordering in a University Hospital Practice
Objective: To examine the diagnostic utility (or misuse) of DAT scanning in a University Hospital practice – is there unnecessary utilisation of DAT scanning when…Effects of exergaming on attentional deficits and dual-tasking in Parkinson’s disease
Objective: To evaluate the effects of exergaming in a controlled six week intervention trial to improve attention-based deficits and dual-tasking in PD when compared to…Assessing the validity and reliability of MANAGE-PD tool to identify patients with Parkinson’s disease inadequately controlled on oral medications – Results from an international survey of general neurologists and movement disorder specialists
Objective: To evaluate the validity and reliability of MANAGE-PD tool. Background: Timely identification of advancing symptoms in patients with Parkinson’s Disease (PD), thereby improving opportunities…Arm levitation as an early manifestation in MELAS syndrome: A case report
Objective: Arm levitation in MELAS syndrome Background: MELAS syndrome has broad manifestations including stroke-like episodes, dementia, epilepsy, lactic academia, myopathy, recurrent headaches, hearing impairment, diabetes and short…Impulse control and repetitive behavior disorders are more common in PD patients with levodopa-induced dyskinesias
Objective: Our aim was to evaluate the prevalence of impulse control and repetitive behavior disorders (ICRB) in patients affected by Parkinson's disease (PD) with and without levodopa-induced…Adult-onset stereotypy — An atypical presentation of frontotemporal dementia
Objective: Describe a case of adult-onset stereotypy with abulia. Background: Stereotypy is a non-goal directed but distractible behavior repeated continuously. While common in the pediatric…Translating Preclinical Data to a Human Equivalent Dose for AMT-130 AAV Gene Therapy for Early Manifest Huntington’s Disease
Objective: To extrapolate the human equivalent dose (HED) for a Phase I/II clinical trial in adults to explore the safety, tolerability, and efficacy of striatally-administered…Prevalence of Huntington’s Disease in Sardinia, Italy
Objective: We have performed a service-based epidemiological analysis extended to the population residing in Sardinia. The socio-cultural isolation of this large Mediterranean island makes genetic…
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