Distributed Global Functional Connectivity Networks Predict Responsiveness to L-DOPA and Subthalamic Deep Brain Stimulation
Objective: To investigate global resting-state functional connectivity (rsFC) patterns associated with response to L-DOPA and to subthalamic nucleus (STN) deep brain stimulation (DBS) in patients…Effect of Subthalamic Deep Brain Stimulation (DBS) on Impulsive Control Disorders (ICD) and Dopamine Dysregulation Syndrome (DDS) – A Randomized Controlled Trial Evaluating Deep Brain Stimulation Using a New Multiple Source, Constant-Current Rechargeable System for Management of Symptoms of Parkinson’s Disease (INTREPID)
Objective: To evaluate impulse control in participating subjects of the INTREPID randomized controlled trial (RCT). Background: Parkinson’s disease (PD) patients undergoing treatment with either medications…Singing – tune into self-regulation: A holistic system perspective
Objective: The aim of the single case experimental study [1] was to examine the treatment of PD under a more holistic systemic perspective similar to…Parakinesia brachialis oscitans due to an acute medial cerebral artery stroke
Objective: To report the case of a patient with a medial cerebral artery acute stroke who developed parakinesia brachialis oscitans after thrombolysis. Background: Although rare, …Predicting the efficacy of STN-DBS in patients with different Parkinson’s disease motor subtypes by preoperative total and partial levodopa response
Objective: To better investigate the value of the challenge test by introducing total and partial LR, and explain the clinical significance of 30% LR through…Kinetic Sensors for Ambulatory Gait and Balance Evaluation in Parkinson’s Disease
Objective: To explore the applicability of an ambulatory inertial sensor (G-walk) to characterize gait function during the Timed Up and Go (TUG) Test. Background: In…The Huntington’s Disease-Behavioral Questionnaire (HD-BQ): A New Screening Tool for Behavioral Disturbances in HD
Objective: To examine the usefulness of a new behavioral questionnaire for patients with, and at risk for, Huntington’s disease (HD). Background: Behavioral changes, including apathy,…Exploring the effects of intrastriatal AAV5-miHTT therapy on MRS signal and mutant huntingtin levels in the Q175FDN mouse model of HD
Objective: To assess the effects of intrastriatal AAV5-miHTT therapy on MRS signal and mutant huntingtin levels in the Q175FDN mouse model of HD. Background: Huntingtin…Factors underlying reduced aerobic capacity in Huntington disease
Objective: Examine factors underlying aerobic capacity in prodromal and manifest Huntington disease (HD) and matched controls Background: HD results in motor impairments, weight loss, muscle…The effect of levodopa-carbidopa intestinal gel relative to optimized medical treatment on dyskinesia: Design and baseline characteristics for an open-label, randomized multicenter 12-week study in advanced Parkinson’s disease patients (DYSCOVER Study)
Objective: The DYSCOVER study will be the first interventional, randomized study to evaluate the comparative effectiveness of levodopa-carbidopa intestinal gel (LCIG) versus optimized medical treatment…
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