Stiff Limb Syndrome Progressing to Stiff Man Syndrome in a non-diabetic man
Objective: Stiff person syndrome is a rare CNS disorder characterized by fluctuating muscle rigidity of truncal and proximal limb muscles with superimposed painful spasms. Involved…A Study of Microglial Metabolism in Neuroinflammation
Objective: Targeting of microglial metabolism may be a potential therapeutic option for diseases such as PD [Parkinson’s Disease] and LBD [Lewy Body Dementia]. To establish…Clinical Audit of Hospital Admissions for Parkinson Disease
Objective: To review Parkinson patients’ admissions and identify possible preventable admissions so as to develop measures to improve care for Parkinson patients Background: Many studies…Investigation of the protective efficacy of alpha-synuclein-specific antibodies in a novel neuronal cell model for synucleinopathies
Objective: To investigate the protective efficacy of different alpha-synuclein (α-Syn)-targeting antibodies in a new model of α-Syn cell-to-cell spread. Background: The 14 kDa protein α-Syn…Wide distribution of alpha-synuclein oligomers in Creutzfeldt-Jakob disease detected by a novel proximity ligation assay
Objective: The objective of this work is to assess if oligomeric forms of alpha-synuclein exist in patients with Creutzfeldt-Jakob disease. Background: Prion diseases, the most…Baicalein incorporated nanoliposome disaggregates alpha-synuclein fibrils
Objective: The aim of this study is to evaluate the depolymerization effect of baicalein on mature fibrils of alpha-synuclein. Background: The aggregation and oligomerization of…GBA-LRRK2 Parkinson’s Disease: a clinical case
Objective: Description of the phenotype of a Parkinson’s disease (PD) patient carrying mutations in both GBA and LRRK2 genes. Background: Monogenic PD due to LRRK2…Carrier Mediated Delivery System Bearing Dopamine for Effective Management of Parkinsonism
Objective: In the present investigation, amino acid coupled liposomes bearing dopamine-HCl were prepared to deliver drug to the brain utilizing receptor-mediated transcytosis for effective management…The role of mitochondria in modifying penetrance of Parkin gene variants
Objective: To understand whether mitochondrial DNA (mtDNA) mutation load can modify the penetrance of variants in the Parkinson’s disease (PD) causing gene PRKN (Parkin), in…The SUNRISE-PD Study, a clinical trial of AXO-LENTI-PD: a CNS-directed gene therapy for the treatment of Parkinson’s Disease
Objective: This presentation will provide an overview of the design and key objectives of the SUNRISE-PD study. Background: Parkinson’s disease (PD) is caused in part,…
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