GBA-LRRK2 Parkinson’s Disease: a clinical case
Objective: Description of the phenotype of a Parkinson’s disease (PD) patient carrying mutations in both GBA and LRRK2 genes. Background: Monogenic PD due to LRRK2…Carrier Mediated Delivery System Bearing Dopamine for Effective Management of Parkinsonism
Objective: In the present investigation, amino acid coupled liposomes bearing dopamine-HCl were prepared to deliver drug to the brain utilizing receptor-mediated transcytosis for effective management…The role of mitochondria in modifying penetrance of Parkin gene variants
Objective: To understand whether mitochondrial DNA (mtDNA) mutation load can modify the penetrance of variants in the Parkinson’s disease (PD) causing gene PRKN (Parkin), in…The SUNRISE-PD Study, a clinical trial of AXO-LENTI-PD: a CNS-directed gene therapy for the treatment of Parkinson’s Disease
Objective: This presentation will provide an overview of the design and key objectives of the SUNRISE-PD study. Background: Parkinson’s disease (PD) is caused in part,…Continuous dopaminergic treatment with levodopa/carbidopa intestinal gel in multiple system atrophy: report of three patients
Objective: To evaluate the effect of continuous dopaminergic treatment with levodopa/carbidopa intestinal gel (LCID) on motor and non-motor symptoms in multiple system atrophy (MSA) patients.…Plasma-based circulating long non-coding RNA AS-Uch1 as a novel diagnostic biomarker for Parkinson’s disease
Objective: The study aimed to validate plasma-based circulating long non-coding RNA (lncRNA) as biomarker for the diagnosis of Parkinson's disease (PD). Background: Parkinson's disease (PD) is…Bilateral INO in PSP
Objective: We describe and demonstrate a patient with PSP who had bilateral internuclear ophthalmoplegia (BINO) with intact convergence on exam. Background: A thorough eye movement…NEUROPSYCHIATRIC SYMPTOMS IN EARLY TO ADVANCED PATIENTS WITH THE RICHARDSON’S SYNDROME VARIANT OF PROGRESIVE SUPRANUCLEAR PALSY
Objective: To know prevalence of neuropsychiatric symptoms in Progressive Supranuclear Palsy along disease stages. Background: Neuropsychiatric symptoms are common features in patients with Progressive Supranuclear Palsy…Cerebellar involvement in progressive supranuclear palsy and corticobasal degeneration
Objective: To investigate cerebellar involvement in vivo in patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) using [18F]FDG PET. Background: Cerebellar ataxia is…Impact of overweight and obesity on functional and clinical outcomes of early Parkinson’s disease
Objective: To determine whether being overweight or obese contributes to disease progression and functional status in Parkinson’s disease (PD). Background: While the tendency of PD…
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