Does Team-based Outpatient Palliative Care Improve Patient or Care Partner-Centered Outcomes in Parkinson’s Disease and Related Disorders?
Objective: To assess whether outpatient palliative care (PC) improves patient or caregiver-centered outcomes in Parkinson’s disease and related disorders (PDRD) compared to current standards of…Effect of Once-Daily Opicapone on the Pharmacokinetics of Repaglinide
Objective: To evaluate the effect of once-daily administration of opicapone 50 mg on the pharmacokinetics (PK) of repaglinide. Background: Opicapone, a highly selective catechol-O-methyltransferase (COMT)…Evaluation of swallowing function by video-fluorography in patients with parkinsonism
Objective: The purpose of the present study is to investigate characteristic patterns of swallowing problems in each clinical entity of parkinsonism including Parkinson’s disease (PD)…Polyneuropathy in patients with continuous levodopa/carbidopa intestinal gel (LCIG) infusion
Objective: To assess frequency of polyneuropathy in patients with LCIG and the usefulness of routine nerve conduction studies follow-up Background: Continuous levodopa infusion is an…Vortioxetine treatment of depression in Parkinson’s disease
Objective: To assess efficacy and safety of Vortioxetine in Parkinson’s Disease (PD) patients affected by depression and its effects on motor performance. Background: Depression is…A phase IIa trial studying the safety and tolerability of IRL752 in patients with Parkinson’s disease dementia
Objective: The primary objective was to investigate the safety and tolerability of IRL752 in PD patients with dementia in a randomized controlled trial. Secondary outcome…Preclinical efficacy of drugs identified by IBM-Watson for repurposing to treat L-DOPA-induced dyskinesia
Objective: To test the efficacy of 3 drugs predicted by IBM Watson for Drug Discovery (WDD) as having the potential to treat L-DOPA-induced dyskinesia (LID).…Exergame training in Early Onset Ataxia patients
Objective: In ambulant EOA children, we aimed to study the effect of a medically designed “ice-skating exergame” on balance, posture and muscle force parameters Background:…POLR3A-related spastic ataxia: new mutations and a look into the clinical and MRI phenotype
Objective: To report the clinical, molecular and magnetic resonance imaging features of eight patients with POLR3A-realted spastic ataxia. Background: POLR3-related disorders comprise a number of…Prospective study of cognition in SCA2
Objective: Evaluate prospectively cognitive dysfunction in subjects with SCA2 using Mini Mental Examination (MMSE) and Montreal Cognition Assesment (MOCA), looking for correlation between cognitiion and motor…
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