Inhibition of mitochondrial complexes induces unique transcriptomic and epigenetic profiles: implications to neurodegeneration induced movement disorders
Objective: To compare the neurotoxicological hallmarks induced by inhibitors of mitochondrial complex I (CI- 1- methyl-4- phenylpyridinium; MPP+), complex II (CII- 3- nitropropionic acid; 3-…Population Exposure-Response Models of Apomorphine Sublingual Film in Healthy Subjects and Patients With Parkinson’s Disease and “OFF” Episodes
Objective: Exposure-response models were developed to characterize the relationship between apomorphine exposure and (1) efficacy using Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease…A possible case of prodromal DLB with prominent hallucinations, autonomic dysfunction, and REM behavior disorder but absence of cognitive impairment
Objective: Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia, after Alzheimer’s disease (AD). While mild cognitive impairment (MCI) is…Neuroprotective effect of Yerba mate (Ilex paraguariensis) in a Drosophila model of Parkinson ’s disease
Objective: To test the neuroprotective capacity of Yerba Mate (YM) in an in vivo model of Parkinson's disease. Background: Parkinson's disease (PD) is caused by the…A flowchart algorithm for the neurologist to discuss and attend sexual issues in Parkinson’s disease
Objective: To propose guidelines for neurologists to discuss sexual issues and offer education and practical solutions. Background: Sexual dysfunction (SD) is a common nonmotor symptom…The role of Parkinson’s disease-associated RHOT1/Miro1 variants in mitochondrial dysfunction and impaired cellular quality control
Objective: In the present study we intent to investigate the effect of mutant Miro1 proteins on mitochondrial function and cellular quality control mechanisms in iPSC-derived…Cerebellar transcranial magnetic stimulation with neuronavigation for postural instability in PSP
Objective: We created a TMS protocol for paired-pulse cerebellar-M1 stimulation and repetitive cerebellar stimulation to augment cerebellar-brain inhibition and reduce postural instability in progressive supranuclear…Synaptic function in Parkinson’s disease associated with GBA mutations
Objective: To investigate the pathological substrate of impaired cognition in Parkinson’s disease (PD) associated with glucocerebrosidase (GBA) mutation. Background: Mutations in glucocerebrosidase gene (GBA), originally…Clinical patterns of gait freezing in Parkinson’s disease and their response to interventions: an observer-blinded study
Objective: To evaluate the occurrence and severity of FOG in provoking situations during a standard video-recorded walking task. To use this method to compare the effects…The effect of coexistent neurodegenerative disorders on the clinical features of idiopathic normal pressure hydrocephalus
Objective: To determine the prevalence of neurodegenerative disorders in idiopathic normal pressure hydrocephalus (iNPH) and their effects on the clinical features of iNPH. Background: To…
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