PRRT2 mutations are associated with a wide intrafamilial ad interfamilial phenotypic variability
Objective: To describe the different clinical syndromes associated with PRRT2 mutations in two different families Background: Mutations in the Proline-Rich Transmembrane Protein 2 (PRRT2) gene…Guided Self-rehabilitation Contracts combined with simultaneous injections of abobotulinumtoxinA into upper and lower limbs in spastic hemiparesis: baseline data from the ENGAGE study
Objective: To report baseline data from ENGAGE, an international phase 3b/4, prospective, single-arm, open-label study (NCT02969356) conducted in France, the Czech Republic, Russia and the USA.…Algorithm of a differentiated approach to the management of patients with tic hyperkinesis
Objective: Develop an algorithm for diagnosis and differentiated approach to the management of patients with tics Background: The prevalence of tics reaches 20%; often accompanied…Is directional stimulation of the VIM superior to omnidirectional stimulation in patients with essential tremor?
Objective: To determine whether directional stimulation of the VIM is superior to omnidirectional stimulation in essential tremor. Background: Deep brain stimulation (DBS) of the VIM…Searching for the optimal functional target for deep brain stimulation in Essential Tremor
Objective: To investigate tremor improvement but also side effects of deep brain stimulation (DBS) for essential tremor (ET) and their relationship to the volumes of…Deep Brain Stimulation of VIM Thalamic Nucleus for Tremor Control
Objective: Compare safety, tolerability, efficiency and efficacy of DBS (VIM DBS) for tremor in Parkinson’s disease (PD) and Non Parkinsonian Patients over 25 years. Background:…A case of donepezil-induced multifocal myoclonus
Objective: To describe the case of a patient who developed severe multifocal myoclonus due to donepezil. Background: Donepezil is a cholinesterase inhibitor frequently used to…Drug-Induced Parkinsonism May Persist Beyond Two Years After Discontinuation of Dopamine Transmission Blocking Agents
Objective: To demonstrate that patients with drug-induced parkinsonism (DIP) can remain symptomatic beyond 6 months, what majority of literature suggests, after withdrawal of causative agents.…A Study of Social Cognition in Parkinson’s Disease
Objective: To study the social cognition in patients with PD and compare it with normal controls Background: Patients with PD have difficulty expressing emotion which…Alterations of Blood Pressure Circadian Rhythm in Alpha-Synucleinopathies
Objective: To analyze the blood pressure (BP) circadian rhythm in Parkinson’s disease (PD), multiple system atrophy (MSA), and pure autonomic failure (PAF), evaluating possible differences…
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