Retinal layer thinning in de novo Parkinson’s disease
Objective: To identify and substantiate the occurrence, extent and location of retinal degeneration in de novo Parkinson’s disease patients (PD) compared to primary open angle…Changes in Neuromelanin MRI Signal in Parkinson’s Disease: A Longitudinal Study
Objective: To investigate the neuromelanin (NM) signal changes in Parkinson’s disease (PD) patients associated with disease progression. Background: PD is characterized by the progressive loss…Role of clinical neuroimaging in X-linked dystonia-parkinsonism
Objective: To determine the inter- and intra-rater reliability of brain imaging in X-linked dystonia-parkinsonism (XDP). Background: XDP is a neurodegenerative movement disorder presenting with adult-onset…Differentiating the substantia nigra pars compacta and ventral tegmental area in early-stage Parkinson’s disease using quantitative susceptibility mapping
Objective: To assess iron levels in dopaminergic midbrain nuclei using quantitative susceptibility mapping for identification of biomarkers of PD. Background: The midbrain dopaminergic system plays…Effective deep brain stimulation co-modulate cross-frequency coupling
Objective: The disruption of pathological signals in the cortico-basal ganglia- network has been hypothesized as a mechanism of action of deep brain stimulation (DBS). However,…Neuronal Network Underlying Speech Difficulties in Parkinson’s Disease
Objective: We aimed to investigate whether speech difficulties are associated with changes in cortical thickness. Background: Speech difficulties are a common debilitating feature of Parkinson’s…Cortical cholinergic dysfunction correlates with microglial activation in the Substantia Innominata in patients with REM sleep behavior disorder
Objective: To explore possible correlations between levels of microglial activation (neuroinflammation) in the Substantia Innominata (SI), the major source of cholinergic input to the cortex,…Evaluation of Imidazoline 2 binding sites reflecting astroglia pathology in Huntington’s Disease: An in vivo [11C]BU99008 PET study
Objective: We aimed to evaluate the role of astroglia activation in Huntington’s disease gene expansion carriers (HDGECs) using [11C]BU99008 PET, a novel radioligand with high specificity and…Park-Ease Trial: A Randomized Controlled Trial to Study the Efficacy of Exercises in Early-Stage Parkinson’s Disease
Objective: To evaluate the efficacy of exercises in early-stage Parkinson’s Disease by observing improvement in motor symptoms assessed by Unified Parkinson’s Disease Rating Scale (UPDRS)…Misdiagnosis in blepharospasm: the common imitators which should not be missed
Objective: Blepharospasm is a focal dystonia whose diagnosis is completely clinical with no blood or imaging biomarker. We observed that sometimes, patients with other disorders…
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