Early-onset parkinsonism and epilepsy: A Tunisian family carrying a novel SYNJ1 mutation
Objective: We report two siblings from a Tunisian family with juvenile Parkinsonism associated with tonic-clonic seizures and good response to levodopa therapy carrying a novel…Microarray analysis upon an synthetic α-synuclein induced model reveals some susceptibility genes in Parkinson’s disease
Objective: To uncover new disease-associated genes and their relevant mechanisms in the pathogenetic process of neurodegenerative disorders, we carried out a gene microarray analysis based…Kufor-Rakeb syndrome and a rare ATP13A2 missense mutation in a Portuguese patient
Objective: To describe a genetically proven case of Kufor-Rakeb syndrome (KRS) in a young portuguese patient with juvenile parkinsonism. Background: Mutations in the ATP13A2 gene…Comparisons of cerebral glucose metabolism and striatal DAT binding in PD patients with and without RBD
Objective: This study aims to identify the differences of functional neuroimaging phenotype between Parkinson’s disease (PD) patients with REM sleep behavior disorder (RBD) (PD+RBD+) and…Compensatory functional activations in early-stage Parkinson’s disease: a cross-sectional motor planning fMRI study
Objective: To assess the dynamic brain responses during planning motor fMRI task in an early-stage cohort of Parkinson’s disease patients. Background: Parkinson’s disease (PD) is…New approach to assess changes in brain activation during real walking using EEG
Objective: To examine the use of EEG during the performance of two well-known paradigms, dual task and oddball, to reveal changes in brain activation during…Neuroinflammation Predicts Dompaminergic Deficit in Early Parkinson Disease: DAT SPECT Imaging Study
Objective: We aimed to investigate whether striatal Dopamine transporter (DaT) uptake could be predicted by Neutrophil to lymphocyte ratio (NLR) or measures of disease severity…Relation of asymmetry of dopamine depletion with motor or non-motor symptoms in patients with Parkinson’s disease: A pilot study
Objective: This study was aimed to investigate whether asymmetry of dopamine depletion through dopamine transporter (DAT) imaging is associated with motor or non-motor symptoms in…Assessing working memory dysfunction with letter n-back functional MRI task in early-stage Parkinson’s disease
Objective: To assess the dynamic brain responses during a working memory n-back fMRI task in an early-stage PD cohort with variable mild cognitive impairment Background:…Remote patient monitoring with a digital biomarker approach generates clinically distinctive and meaningful sensor feature data in Parkinson’s disease: Differential relationships with MDS-UPDRS-III, PDQ-39 and DaT-SPECT
Objective: To determine whether sensor features derived from remote smartphone testing in Parkinson’s disease (PD) predicted clinical, quality of life and biomarker measures collected in…
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