Autonomic Dysfunction in Parkinson’s Disease: Role of New Surrogate Markers
Objective: The physiology of respiration is modulated by autonomic efferent neurons and circulating hormones. A continuous ambulatory monitoring of various respiratory parameters helps in early…Assessment of pain and its correlation with quality of life in Parkinson’s disease
Objective: The study was carried out to assess the prevalence of pain, nature of pain, quality of life and correlation of pain with quality of…Selection of odorants for diagnosis of Parkinson’s disease
Objective: The goal of this study was to identify the subset of Sniffin Sticks Test odorants that could be used to differentiate patients with Parkinson’s…Preclinical cardiovascular sympathoexcitatory effects of TD-9855, a novel norepinephrine transporter (NET) inhibitor in development for the treatment of symptomatic neurogenic orthostatic hypotension (nOH) in patients with primary autonomic failure
Objective: TD-9855 is a novel NET inhibitor (1) being studied for the treatment of symptomatic nOH. The objective of the present study was to characterize…Visual deficits of self-motion perception in Parkinson’s disease
Objective: To investigate unisensory and multisensory self-motion perception mediated by the visual and vestibular systems in PD. Background: Parkinson's disease (PD) is classically characterized by…Levodopa and subthalamic stimulation do not have the same effect on subjective cost for distal and axial efforts in Parkinson’s disease
Objective: To compare the effects of levodopa and subthalamic nucleus stimulation (STN-DBS) on decision-making tasks for distal (hand) and axial (speech) efforts in Parkinson’s disease…Low body weight is associated with poor functional status in Parkinson’s disease (PD)
Objective: To assess if low body weight and malnutrition is associated with poor functional status in PD. Background: It has been observed that many advanced…Apathy in Parkinson’s disease is associated with abnormal alpha oscillatory behaviour during incentivized movement
Objective: To determine the relation between apathy and neural oscillations in Parkinson’s disease (PD). Background: Apathy in PD, characterized by lack of motivation, is often…Multisite Tissue and Biofluid Sampling for Alpha-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
Objective: To characterize the distribution of alpha-synuclein (aSyn) pathology in multiple tissues and body fluids within the same Parkinson’s disease (PD) subjects and compared to…Serum glutamate is associated with the motor subtype of Parkinson’s disease
Objective: We aimed to study the concentration of glutamate in the serum of patients with Parkinson's disease (PD) and its connection with clinical variants of…
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