Intranasal delivery of insulin for the restoration of memory signaling in Alzheimer disease
Objective: Objective of this study is to develop delivery-system to overcome BBB by employing novel, non-invasive approach via nasal route. Background: Alzheimer's disease(AD), a form…Effects of Botulinum Toxin treatment for sialorrhea in patients with cerebral palsy
Objective: To evaluate the benefits of treatment of drooling with Botulinum Toxin Type A (AbobotulinumtoxinA) in patients with cerebral palsy. Background: Patients with cerebral palsy…A Randomized Trial of Deferiprone for Pantothenate Kinase-Associated Neurodegeneration
Objective: To investigate whether treatment with the iron-chelating drug deferiprone (DFP) has benefit in patients with pantothenate kinase-associated neurodegeneration (PKAN), the most common form of…A novel homozygous splice site mutation in the KIF1C gene (SPAX2, SPG58) found in a consanguineous turkish family
Objective: We present clinical, electrophysiological and genomic data of a consanguineous family with two affected siblings suffering from spasticity and severe ataxia. Background: Mutations in…Targeting GPi: DBS Treating Dystonia in a Patient with Wilson’s Disease
Objective: The primary objective is to determine the efficacy of Deep Brain Stimulation (DBS) targeting the internal segment of the globus pallidus (GPi) on treating…The change of heart rate variability after subthalamic nucleus deep brain stimulation in patients with Parkinson’s disease: A Meta⁃analysis
Objective: To evaluate the changes of heart rate variability (HRV) after subthalamic nucleus deep brain stimulation (STN-DBS) in patients with Parkinson’s disease (PD). Background: The…Directional DBS: A new algorithm to determine lead rotation
Objective: To establish a pipeline for reliable determination of lead rotation in directional DBS. Background: New directional leads with segmented electrodes are now widely used…Hemidystonia due to midbrain hemorrhage: An unusal complication of Deep Brain Stimulation
Objective: In this case report, we describe the development of hemidystonia due to hemorrhagic complication after subthalamic deep brain stimulation (STN-DBS) in a patient with…Gradient-like representation of emotional valence and arousal within the subthalamic nucleus in Parkinson’s disease
Objective: We aimed to analyze the relationship between the active electrode position within the subthalamic nucleus (STN) and subjective emotional experience in Parkinson’s disease (PD)…Estimates of cost and saving effects of increasing rechargeable devices on the sustainability of a deep brain stimulation program
Objective: 1) To estimate deep brain stimulation (DBS) material costs for a 6-year-period at our institution considering two scenarios: a conservative one focused on gradual…
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