A phase Ib trial studying the safety and tolerability of IRL790 in patients with Parkinson’s disease and levodopa-induced dyskinesia
Objective: The primary objective was to investigate the safety and tolerability of IRL790 in PD patients with LID in a randomized controlled trial. Background: IRL790…Quantifying the Reproducibility of an In Vivo Assay: Examination of Historical Amantadine Effects in the macaque Model of L-DOPA-Induced Dyskinesia
Objective: This study was designed to assess the reproducibility of the amantadine anti-dyskinetic effect in the MPTP L-DOPA-Induced Dyskinesia (LID) macaque model for soundly defining…Can blood biomarkers differentiate Idiopathic Parkinson’s disease from Parkinson plus syndromes? A study from North Indian population
Objective: To study the role of serum DJ-1 and Apo A1 in the differentiation of Idiopathic Parkinson Disease (IPD) and Parkinson Plus Syndromes (PPS) in…PROtein, LEucine And vitamin D Enhancing Rehabilitation (PRO-LEADER) in patients with Parkinson’s disease or parkinsonism: A RCT
Objective: We evaluated the efficacy of a muscle-targeted nutritional support on the outcomes of a multidisciplinary intensive rehabilitation treatment (MIRT). Background: Physical rehabilitation is an…Eye Movement Abnormalities Correspond to Pontine Atrophy in Wilson Disease
Objective: This study aims to characterize eye movement (EM) abnormalities in Wilson´s disease (WD) and to assess their relation to clinical severity of WD and…Transient dystonia of infancy: 25 cases
Objective: Characterize a group of pediatric patients with transient dystonia of infancy. Background: Transient dystonia of infancy is a Developmental and Benign Movement Disorder characterized…Cerebrotendinous Xanthomatosis: A heterogeneous condition
Objective: Cerebrotendinous xanthomatosis(CTX)is a relentless progressive disorder with treatment predominantly preventive,so early diagnosis is crucial.The object of this study is to evaluate clinical manifestations and…Bilateral subthalamic deep brain stimulation combined with thalamotomy for PRRT2-associated generalized dystonia: A case report
Objective: To investigate the efficacy of deep brain stimulation (DBS) and thalamotomy on symptoms improvement in a case of PRRT2-associated childhood-onset generalized dystonia. This would…Long term clinical outcome after deep brain stimulation of the thalamic VIM in Holmes Tremor: A case series
Objective: The clinical course and long term outcome up to 5 years post surgery of a sample of 4 patients with medical refractory HT who…Pulvinar low intensity on susceptibility-weighted imaging may predict cognitive worsening after deep brain stimulation therapy in Parkinson’s disease patients
Objective: This study was undertaken to predict cognitive worsening by pulvinar imaging in susceptibility-weighted imaging (SWI). Background: Deep brain stimulation (DBS) for Parkinson’s disease (PD)…
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