Intranasal delivery of insulin for the restoration of memory signaling in Alzheimer disease
Objective: Objective of this study is to develop delivery-system to overcome BBB by employing novel, non-invasive approach via nasal route. Background: Alzheimer's disease(AD), a form…Effects of Botulinum Toxin treatment for sialorrhea in patients with cerebral palsy
Objective: To evaluate the benefits of treatment of drooling with Botulinum Toxin Type A (AbobotulinumtoxinA) in patients with cerebral palsy. Background: Patients with cerebral palsy…A Randomized Trial of Deferiprone for Pantothenate Kinase-Associated Neurodegeneration
Objective: To investigate whether treatment with the iron-chelating drug deferiprone (DFP) has benefit in patients with pantothenate kinase-associated neurodegeneration (PKAN), the most common form of…Quantitative oculomotor assessment and non-motor biomarkers in late-onset GM2 gangliosidosis
Objective: To assess whether quantitative eye movement measures correlate with disease severity in late-onset GM2 gangliosidosis, and to perform exploratory assessments of novel cognitive/neuropsychiatric measures…Longitudinal follow-up of dual-lead thalamic deep brain stimulation for patients with treatment refractory multiple sclerosis tremor
Objective: To report long-term outcome measurements of tremor control in patients with medically refractory multiple sclerosis tremor and dual lead thalamic deep brain stimulation. Background:…Comparison of Mattis and MOCA testing for neuropsychological assessment in the preoperative evaluation of subthalamic nucleus stimulation in Parkinson´s disease
Objective: The aim of the current study is to evaluate, whether 1. MOCA (Montreal Cognitive Assessment) and Mattis tests are equivalent in the detection of…Comparative results between preoperative acute levodopa challenge test and deep brain stimulation
Objective: Our aim is to compare motor clinical benefits after acute levodopa challenge test, with those obtained further with deep brain stimulation (DBS). Background: DBS…Deep brain stimulation for monogenic Parkinson’s disease: A systematic review
Objective: The aim was to systematically investigate the outcome of deep brain stimulation (DBS) in genetic Parkinson’s disease (PD) compared to the patients with documented…Long-term effect of low frequency stimulation of STN on dysphagia, freezing of gait and other motor symptoms in PD
Objective: To evaluate the long-term effect of 60Hz low frequency stimulation (LFS) of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other…Directional DBS; clinical experience at Unit of Functional Neurosurgery. Ramón y Cajal University Hospital,Madrid, Spain
Objective: to determine the practicabillity of using an image guide programming setting in our clinical practice. Background: The applicability of DBS leads and systems that…
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