Submandibular gland is a suitable tissue for alpha synuclein pathology in Parkinson’s disease
Objective: To validate the role of α-synuclein (AS) pathology in submandibular gland (SMG) as a biomarker for Parkinson disease (PD). Background: The pathologic hallmark of…STN-DBS responsive motor complication and pathological gambling in type IV SCA3
Objective: Background: Type IV spinocerebellar ataxia type 3 (SCA3) could present as pure parkinsonism. A bilateral subthalamic nucleus deep brain stimulation (STN-DBS) has been reported…CRISPR/Cas9-based fluorescent tyrosine hydroxylase-reporter lines
Objective: To generate and characterize TH-GFP and -mCherry reporter iPSC lines. Background: Human induced pluripotent stem cells (iPSCs)-based dopaminergic neuronal (iDA) cultures emerged as a…Improving compliance to Parkinsonism’s pharmacotherapy amongst patients attending a Movement Disorders Clinic (MDC)
Objective: To improve patients’ compliance with Parkinsonism's pharmacotherapy to achieve more accurate clinical assessment in an outpatient setting. Background: Patients with Parkinsonism are encouraged to…What increases the risk of malnutrition in geriatric Parkinson’s disease population?
Objective: The aim of the this study is to determine the risk of the malnutrition in geriatric Parkinson's disease population. Background: Among the patients with…Non-motor symptoms in patients from the Catalonian Multiple System Atrophy Registry (CMSAR)
Objective: To assess non-motor symptoms (NMS) and their demographic and clinical correlates in MSA patients included in the CMSAR. Background: NMS are an important and…ARISE study: Study Design and Baseline Characteristics for a Phase 2 Trial of the Anti-Tau Antibody ABBV-8E12 in Progressive Supranuclear Palsy
Objective: This double-blind, placebo-controlled phase 2 study (M15-562 ARISE study, NCT02985879) assesses the safety and efficacy of ABBV-8E12 treatment in patients with progressive supranuclear palsy…Motor and cognitive deficits in a mouse model of tauopathy with tau isoforms imbalance: Potential therapeutic strategies
Objective: This work investigates motor phenotypes and neurochemical changes in a mouse model of tauopathy linked to tau mis-splicing. We sought to validate a potential…Midbrain/pons area ratio and clinical features predict the prognosis of PSP
Objective: This study aims to characterize the natural history of PSP and to find predictors of shorter survival and early institutionalization including neuroimaging biomarkers. Background:…Affective impairment and emotional tone of early Richardson’s syndrome and Progressive Supranuclear Palsy with predominant parkinsonism: The role of Alexithymia and Anhedonia
Objective: To define qualitative and quantitative differences of alexithymia and anhedonia among Progressive Supranuclear Palsy (PSP) with predominant parkinsonism (PSP-P), Richardson’s syndrome (PSP-RS) and Parkinson’s…
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