Predicting Alpha-Synuclein Pathology by REM Sleep Behavior Disorder Diagnosis
Objective: Determine sensitivity, specificity and predictive value of clinician diagnosed probable REM sleep behavior disorder (PRBD) in predicting alpha-synuclein pathology. Background: Inability to accurately diagnose…Parkinsonism with rare sequence variants in VPS35 and FBXO7 genes associated with Lewy body pathology
Objective: To detect a neuropathological background of parkinsonism associated with rare sequence variants in the VPS35 and FBXO7 genes. Background: A total of 23 gene…Adolescent onset RBD converting to PD after 48 years
Objective: To present a patient with adolescent onset dream enactment behaviour who developed PD 48 years later. Background: RBD typically occurs after age 50, and…Rotenone model of Parkinson’s disease: The dosing options in mice revisited
Objective: In the present study we have used various dosing protocols to induce the PD-like symptoms with the administration of rotenone in mice. Background: Parkinson's…Approaching Health Care Shaped by Generational Expectations (The AGE Study): Generational Perspective Related to Time
Objective: To investigate the preferences different generational groups (i.e. Traditionalists, Baby Boomers, Generation X-ers, and Millennials) have towards healthcare with regards to time management. Background:…Reversible Extrapyramidal features as unusual presentation of central pontine myelinolysis: A case report
Objective: To be acquainted with the extrapyramidal symptoms developed during the course of central pontine myelinolysis. To emphasize the importance of neuroimaging in the diagnosis…A case of levodopa responsive rapid onset dystonia-parkinsonism
Objective: We describe and demonstrate by video a young man with rapid onset dystonia parkinsonism who has a robust response to levodopa. Background: Rapid onset…Methylphenidate in Progressive Supranuclear Palsy [PSP] – Old drug, New Indications?
Objective: To evaluate whether Methylphenidate can improve some symptoms of PSP. Background: PSP is a neurodegenerative disorder with limited therapeutic options. Methylphenidate[MPH] , a drug…The role of substantia nigra sonography in the differentiation of Parkinson’s disease and multiple system atrophy
Objective: To evaluate the differential diagnosis value of transcranial sonography (TCS) between Parkinson’s disease (PD) and multiple system atrophy (MSA) Background: The differential diagnosis of…Disease progression and survival of multiple system atrophy: A prospective French cohort study
Objective: We report the first prospective natural history study of MSA combining progression of the disease and mortality. Background: Multiple system atrophy (MSA) is a…
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