PLG restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models
Objective: Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease and there are few treatments currently available. The present study investigated…Rationale and Design of an Open-Label, Randomized, 26-Week Study Comparing Levodopa-Carbidopa Intestinal Gel to Optimized Medical Treatment on Non-Motor Symptoms in Patients with Advanced Parkinson’s Disease – INSIGHTS Study
Objective: To examine levodopa-carbidopa intestinal gel, LCIG (also known as carbidopa-levodopa enteral suspension in the US), on non-motor symptoms (NMS) compared with individually-optimized, conventional PD…Relationship between CTG repeats, Muscle Weakness and Respiratory Dysfunction in Myotonic Dystrophy Type 1
Objective: This study aims to assess the association between CTG repeats, muscle weakness and respiratory dysfunction in a cohort of individuals with myotonic dystrophy type…VIT-D and Tics Movement Disorder
Objective: Tics is common childhood movement disorder, with classified variants , typically begin at around 4-5 years of age but often present later at about…High dose of levodopa and Segawa disease
Objective: To analyze the dose-dependent effects of levodopa on the symptoms of the disease in our case. Background: In 1976, Segawa et al. reported dopa-responsive…Improvement in chorea and function in a patient with dystonia-choreoathetosis cerebral palsy after treatment with bilateral pallidal deep brain stimulation
Objective: We describe and demonstrate by video a patient with dystonia-choreoathetosis cerebral palsy treated with bilateral pallidal deep brain stimulation (DBS). Background: Dystonia-choreoathetosis cerebral palsy…Long-term habituation of deep brain stimulation for essential tremor: An observer-blinded study
Objective: Deep brain stimulation (DBS) of the thalamic ventrointermedius nucleus (Vim) is an accepted treatment for severe, drug-resistant essential tremor. There is an ongoing debate…Impact of Subthalamic Nucleus Stimulation on Striatal Dopamine Transporter in Parkinsonian Rat Models
Objective: To investigate the impact of subthalamic nucleus deep brain stimulation (STN-DBS) on striatal dopamine transporter (DAT) of Parkinsonian rat models. Background: STN-DBS has become…A Patient-Centered Decision-Making Algorithm for Deep Brain Stimulation Surgery in Parkinson’s Disease
Objective: To develop a computer application with responsive design to incorporate Parkinson’s Disease (PD) patients’ expectations for Deep Brain Stimulation (DBS) surgery and present them…Spontaneous peri-electrode edema, 7 years after subthalamic nucleus deep brain stimulation (STN-DBS) in a patient with Parkinson´s disease (PD): A case report
Objective: To describe an infrequent and late complication of STN-DBS in a patient with PD. Background: DBS is a safe procedure for patients with PD.…
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