Acute efficacy and tolerability of the COMT inhibitor opicapone
Objective: Evaluation of the acute efficacy and tolerability of Opicapone. Background: Opicapone is a Catechol-O-Methyltransferase (COMT) inhibitor for the treatment of patients with idiopathic Parkinson’s…Characteristics of dopaminergic treatments in advanced Parkinson’s before levodopa-carbidopa intestinal gel infusion: Data from 107 tested patients
Objective: To describe the characteristics of dopaminergic treatments in a large group of patients with advanced Parkinson’s Disease (APD) in which current non-invasive therapy (oral,…Effects of Expiratory Muscle Strength Training and Voice Therapy on Parkinsonian Speech
Objective: The current study compared the effects of expiratory muscle strength training (EMST) and EMST plus voice therapy (VT) on speech loudness and intelligibility of…A novel non-nitrocatechol COMT inhibitor ODM-104 shows superior pharmacodynamic effects to entacapone
Objective: ODM-104 is a novel non-nitrocatechol catechol-O-methyltransferase (COMT) inhibitor that is undergoing clinical evaluation for Parkinson’s disease (PD). This study investigated the pharmacodynamic effects of…Multimodal evoked potential analysis in Woodhouse-Sakati Syndrome
Objective: Investigate Woodhouse-Sakati syndrome through analysis of multimodal evoked potentials at various clinical stages, to assess their possible role as an aid in determining the…Movement disorder masquerading as seizure disorder
Objective: The main objective of presenting this case report is to emphasise the importance of accurate clinical diagnosis of movement disorder in children which many…Juvenile parkinsonism associated with a novel HSD17B10 mutation in a patient with HSD10 disease
Objective: We describe the case of a female patient with HSD10 disease associated with parkinsonism, with a novel mutation in the HSD17B10 gene. Background: HSD10…An early-onset parkinsonism revealing a Gaucher disease with a heterozygous mutation in GBA gene: A case report
Objective: To report a case of a late-onset Gaucher disease (GD) revealed by an atypical Parkinson disease. Background: GD is an autosomal recessive lysosomal disorder,…Effect of Thalamic Deep Brain Stimulation in Isolated Dystonia Associated with Prominent Tremor
Objective: To report the outcomes of a series of isolated dystonia patients with prominent tremor treated with thalamic deep brain stimulation (DBS). Background: Pallidal and…Optimized Imaging at 3.0 T of the Rostral Zona Incerta (rZI) for Deep Brain Stimulation (DBS) in Parkinson’s Disease (PD)
Objective: To improve upon imaging of the rostral zona incerta (rZI) allowing for direct targeting during deep brain stimulation. Background: DBS of the subthalamic nucleus…
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