Application of the Movement Disorder Society Prodromal Criteria in healthy G2019S-LRRK2 carriers
Objective: To evaluate the MDS prodromal criteria in first-degree relatives of Ashkenazi Jewish G2019S-LRRK2 PD patients, who are considered a population at risk for developing…Early-onset Parkinson’s disease in seven patients with heterozygosity for parkin mutation
Objective: To present and discuss a series of 7 patients with early-onset Parkinson’s Disease and heterozygosity for PARK2 mutation. Background: Parkin mutation in homozygosity or…Molecular-genetic nature of Parkinson’s disease in the East European cohort
Objective: Genetic testing of the Parkin gene in patients with Parkinson's Disease (PD) in the East European cohort from Belarus. Background: The diagnosis of Juvenile…A founder French-Canadian GBA mutation, p.W378G, as a cause for synucleinopathies and Gaucher disease
Objective: To examine and characterize founder GBA mutations in the French-Canadian (FC) population Background: GBA mutations are the most common genetic risk factors for Parkinson’s…Does dopaminergic denervation of specific anatomical regions of the basal ganglia correlate with clinical features of Parkinsonism: A quantitative DaTscan study
Objective: To correlate different clinical features of parkinsonism with regional variations of presynaptic dopaminergic dysfunction of the basal ganglia using quantitative DaTscans. Background: DaT-SPECT imaging…Clinical and functional network features of visuoperceptual disturbances in Parkinson’s disease
Objective: To clarify the relationship between functional connectivity changes in the brain and visuoperceptual disturbances in patients with Parkinson's disease (PD). Background: Patients with PD…Contribution of individual motor signs to striatal dopamine deficiency in parkinsonism
Objective: The primary aim of the study was to investigate if any individual motor sign could be used clinically to predict striatal dopamine deficiency. Secondary…A comprehensive digital biomarker active testing and passive monitoring suite for the remote and frequent assessment of motor symptom progression in Parkinson’s disease
Objective: We present the development and design of a comprehensive digital biomarker smartphone application (app) for remote and frequent assessments of motor symptom severity and…Altered putamen and cerebellum connectivity between different subtypes of Parkinson’s disease
Objective: we investigate the functional connectivity (FC) patterns of the putamen between different subtypes of PD) and healthy controls, and explore its clinical significance. Background:…Discriminating Idiopathic PD Patients and Controls in PPMI Using Integrative Multi-Modal Neuroimaging Analysis with Graph Convolutions
Objective: To discriminate Parkinson’s disease (PD) patients and controls in the Parkinson’s Progression Markers Initiative (PPMI) cohort according to MRI features using a novel a…
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