Dissecting molecular signatures of X-linked dystonia-parkinsonism (XDP) through integrative genomics studies
Objective: To determine the causal locus and functional mechanism associated with XDP using integrative genomics methods in patient-derived and genome-edited induced pluripotent stem cell (iPSC)…The History of Huntington Disease Description in Russia
Objective: The report provides detailed material on the history of the description of Huntington's disease (HD) in Russia. The first, unknown to a wide audience,…“Wine glass” appearance in a primary lateral sclerosis and frontotemporal dementia case
Objective: Primary lateral sclerosis is a very uncommon progressive disease and represents 2-4% of motor neuron diseases group. It is characterized by spasticity because corticospinal…The shared risk of apolipoprotein E ɛ4-allele on hippocampal volume across the spectrum of Alzheimer’s disease and dementia with Lewy bodies: Evidence from the Sunnybrook Dementia Study
Objective: To identify the association of apolipoprotein E ɛ4-allele (APOE-ε4) with hippocampal volumes across the spectrum of Alzheimer’s disease (AD) and dementia with Lewy bodies…Could curcumin be the preventive key of parkinson’s disease?
Objective: The present study evaluates the possible protective effect of curcumin on rats exposed to aluminum which is a major risk factor of parkinson's disease.…Asymmetry of pallidal neuronal activity correlates with head rotation in patients with cervical dystonia
Objective: To find correlation between single unit activity in globus pallidus (GP) and neck turning in patients with cervical dystonia (CD). Background: Asymmetric GP local…SYN120 (a Dual 5-HT6/5-HT2A Antagonist) Study to Evaluate Safety, Tolerability and Efficacy in Parkinson’s Disease Dementia (SYNAPSE): Phase 2a Study Results
Objective: To evaluate the safety and preliminary efficacy of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is an antagonist of serotonin receptors…Delayed-onset Edema Surrounding Deep Brain Stimulation Leads: Insights From A Case Series and Literature Review
Objective: We report a case that showed Postoperative cerebral edema around a deep brain stimulation (DBS) electrode and review the literature to explore its possible causes. Background: Deep brain…A Study to Evaluate the Efficacy of PRX002/RG7935 in Participants With Early Parkinson’s Disease (PASADENA) – Study Design
Objective: To evaluate the efficacy of the anti-alpha-synuclein monoclonal antibody PRX002/RG7935 in a proof-of-concept Phase 2 study in patients with early Parkinson’s disease (PD). Background:…Study On Patient- And Caregiver-Reported Symptoms And Outcomes With Levodopa-Carbidopa Intestinal Gel For The Treatment Of Advanced Parkinson’s Disease. ADEQUA Study
Objective: The primary objective of the present study was to assess the effect of levodopa-carbidopa intestinal gel (LCIG) on the QoL of patients with advanced…
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