Association analysis of the nutritional status and serum nutritional index in patients with Parkinson’s disease
Objective: This study was conducted to determine the associations between the nutritional status and serum nutritional index and motor symptoms among patients with Parkinson’s disease(PD).…Ondansetron, a highly-selective 5-HT3 receptor antagonist, alleviates L-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson’s disease
Objective: To determine the effectiveness of selective serotonin 3 (5-HT3) receptor blockade at reducing the severity of established, and preventing the development of, dyskinesia. Background:…Effects of JN403, an α-7-nicotine-acetylcholine-receptor (α7-nAChR) agonist on human alpha-synuclein-mediated in vitro and in vivo models of Parkinson’s disease
Objective: To investigate whether JN403, a novel selective agonist of α-7-nicotine-acetylcholine-receptors (α7-nAChRs) can suppress inflammation and toxicity in human alpha-synuclein (αSyn) induced in vitro and…Influence of baseline OFF-time in the efficacy response of opicapone in Parkinson’s disease patients with motor fluctuations: The BIPARK-I double-blind experience
Objective: To evaluate the efficacy of opicapone (OPC) in levodopa-treated Parkinson’s Disease (PD) patients with motor fluctuations and subdivided by their baseline OFF-time. Background: OPC,…A first-in-human clinical study to test the safety and preliminary efficacy of CDNF in Parkinson’s disease
Objective: To develop a novel disease-modifying therapy in Parkinson's disease (PD) that affects both motor and non-motor symptoms, based on a novel stress-protective protein CDNF.…Augmented Reality-Based Dance Application on Balance and Mobility of Individuals with Parkinson’s Disease: A Pilot Study
Objective: To investigate the acute and long-term effects of a mobile, augmented reality-based extension of Dance for PD® classes on balance and mobility in persons…Basal Ganglionic Lesions in Egyptian Children: Radiological Findings in Correlation with Etiology and Clinical Manifestations
Objective: to determine the etiology of basal ganglionic disorders in a sample of Egyptian children. Background: In childhood, the metabolic activity of the basal ganglia…Exosomal alpha synuclein secretion is beneficial for cellular models of Kufor-Rakeb syndrome
Objective: The purpose of this study is to investigate the effect of induction of exosomal a-syn secretion on PARK9-mediated neurotoxicity. Background: Kufor-Rakeb syndrome (KRS) is…Biological course and natural history of hereditary spastic paraplegia type 11 (SPG11)
Objective: We aim to establish biological markers for the natural history and course of hereditary spastic paraplegia (HSP) type 11 (SPG11) using multiple readout parameters…Patient with secondary dystonia treated with internal globus pallidus deep brain stimulation (GPi-DBS), 2 years results: A case report
Objective: To assess long term benefit of multiple source steering of GPi-DBS in a patient with secondary dystonia due to kernicterus related perinatal encephalopathy. Background:…
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