Botulinum toxin injections improve daily life activities in patients with upper limb tremor
Objective: To describe a group of patients with an upper limb tremor refractory to per os medications and receiving Botulinum NeuroToxin type A (BoNT-A) injections.…Neurocognitive outcomes of STN-DBS in patients with Parkinson’s disease: A 10-year review of local experiences in Hong Kong
Objective: The purpose of the study was to determine the long-term neurocognitive outcomes of STN-DBS for PD. Background: Cognitive disturbances is one of the most…Effect of different normative samples and cut-off values on determination of cognitive impairment in the Parkinson’s Progression Marker Initiative
Objective: Compare cognitive performance in participants with Parkinson Disease (PD) utilizing published normative data versus age-stratified norms from the Parkinson’s Progression Marker Initiative (PPMI) healthy…Opposite effects of dopamine on specific NoGo perfomance in young and late onset Parkinson’s disease and the relationship to nigrostriatal degeneration
Objective: To investigate inhibitory control under dopamine (DA) in Parkinson’s disease (PD). Background: The pattern of degeneration in PD as well as side effects of…Turning during gait is associated with gray matter density of the nucleus basalis of Meynert in Parkinson’s disease
Objective: To examine whether turning during gait is associated with gray matter (GM) density of the nucleus basalis of Meynert (nbM) and attention in people…Early synaptic loss and synaptic instability in a mouse model of prodromal Parkinson’s disease
Objective: In order to elucidate very early pathologis of Parkinson’s disease (PD), we focused on synaptic pathologies in a newly developed mouse model of prodromal…Knockdown of eEF1A2 reduced neuronal survival in a SH-SY5Y cellular model of Parkinson’s disease through the PI3K/Akt/mTOR pathway
Objective: To investigate whether eEF1A2 promotes neuronal survival through PI3K/Akt/mTOR pathway in a toxin-induced Parkinson’s disease model. Background: Parkinson’s disease is a common neurodegenerative disorder…Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) -mediated ubiquitination attributed to localization of Mortalin to mitochondria
Objective: The pathogenic mechanism of UCHL1 in PD remains unclear. In this study, we aimed to investigate the role of UCHL1 in the pathogenesis of…Relationship between cyclooxygenase-2 gene polymorphisms and Parkinson’s disease susceptibility in Chinese Han population
Objective: To investigate relationship between the cyclooxygenase-2 (COX-2) gene promoter region (rs20417, rs689466, rs689465) and 3'untranslated region (rs5275) polymorphisms with Parkinson’s disease (PD) susceptibility in…Frequency of the LRRK2 and GBA mutations in Russian population with Parkinson’s disease
Objective: To estimate the frequency of LRRK2 mutation (G2019S) and GBA mutations (N370S, L444P) and polymorphic variants (E326K, T369M) in PD and controls in the…
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