Study on feasibility to develop a central nervous system (CNS) Leucine-rich repeat kinase 2 (LRRK2) PET tracer
Objective: To assess feasibility of developing a CNS LRRK2 PET tracer. Background: LRRK2 enzyme belongs to the leucine-rich repeat kinase family. Pathogenic mutations in the…Evaluation of bradykinesia in Parkinson’s disease using a computerised evolutionary algorithm
Objective: Application of a computerised algorithm to kinematic motor recordings to distinguish parkinsonian bradykinesia from normal movement. Background: Bradykinesia, the only obligatory physical sign for…Combined Neurite Orientation Dispersion and Density Imaging and Myelin Imaging Provide New Insights to White Matter Changes of the Neurocognitive-psychiatric Disorder in Parkinson’s Disease
Objective: To identify white matter (WM) changes in PD with neurocognitive-psychiatric symptoms (NPS) using neurite orientation dispersion and density imaging (NODDI) and magnetization transfer saturation…Validation of the new diagnostic criteria for fatigue in Parkinson’s disease
Objective: The aim of this study was to validate the new diagnostic criteria for fatigue1 in Parkinson’s disease patients. Background: Case definition and diagnostic criteria…Burden of Eye disease in Parkinson’s disease (PD)
Objective: To review the burden of eye pathologies in patients with Parkinson’s disease. Background: Parkinson’s disease and eye problems are common in older patients. Alterations…Study of prevalence of non-motor symptoms in typical and atypical parkinsonism as compared to age and sex matched healthy controls
Objective: 1) To study prevalence and clinical characteristics of non-motor symptoms (NMS) in idiopathic parkinson disease (IPD) and atypical Parkinsonism (APD) as compared to age…Is REM sleep behavior disorder associated with excessive daytime sleepiness in military veterans with Parkinson’s disease?
Objective: To determine if REM sleep behavior disorder (RBD) is associated with excessive daytime sleepiness (ES) in military veterans with Parkinson’s disease (PD). Background: Nearly…Multimorbidity predicts quality of life but not motor severity in early Parkinson’s disease
Objective: To explore the associations between multimorbidity, severity of motor symptoms, and quality of life (QoL) in people with early PD. Background: Multimorbidity is defined…Gastrointestinal Symptoms and Enteric Nerve Dysfunction in A53T Mice
Objective: To investigate the relationship between α synucleinopathy-induced enteric neuropathy and gastrointestinal dysfunction in A53T mice. Background: Approximately 80-90% of PD patients suffer from GI…Degeneration of vagus nerve but not of accessory and phrenic nerve in Parkinson’s disease revealed by high-resolution ultrasound
Objective: To test the hypothesis that the vagus nerve is measurably atrophic in idiopathic Parkinson’s disease (PD). Background: The vagus nerve is discussed to represent…
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