Presence of Lewy dots in the brain of patients with Creutzfeldt-Jakob disease
Objective: We have investigated whether alpha-synuclein deposits exists in the brain of patients with Creutzfelt-Jakob disease Background: Creutzfeldt-Jakob’s disease (CJD) is a prion neurodegenerative disorder…Cell and animal models lacking RAB39B show biochemical and behavioural phenotypes that model aspects of Parkinson’s disease
Objective: To determine the pathogenic mechanisms underlying RAB39B-mediated Parkinson’s disease (PD). Background: PD is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the…Determination of falling direction in Parkinson’s disease patients using a wearable sensor
Objective: The aim of this study is to objectively detect falls and their direction in Parkinson’s disease (PD) patients during everyday activities. Background: Falling is…Neuroprotection effects of probiotics strains on a chronic MPTP-induced mouse model of Parkinson’s disease
Objective: To explore the effects of probiotics strains on the neuroinflammation and degeneration of dopaminergic neurons in chronic Parkinson’s disease (PD) mice model. Background: Microglia-mediated…Speech intelligibility and comprehensibility in Slovak patients with Parkinson’s disease
Objective: The aim of our study was to evaluate intelligibility and comprehensibility (intelligibility in context) and its relationship with MDS-UPDRS (sub)scores in Slovak population of…α-synuclein antibody 5G4 identifies manifest and prodromal Parkinson’s disease in colonic mucosa
Objective: The aim of this study was to evaluate colonic mucosa staining using the 5G4 antibody, specific only for the disease-associated form of α-synuclein, in…Personality Traits and Sleep Quality in Parkinson’s disease patients
Objective: To investigate which types of personality traits are related to sleep quality in Parkinson’s disease (PD) patients. Background: Sleep disturbance is a common nonmotor…Intercultural differences in the frequency of impulsive control disorders in Parkinson’s disease
Objective: To study if there were intercultural differences in the prevalence of these impulse control disorders in PD. Background: Impulse control disorders (ICD) era common…Assessing hemifacial spasm: The HFSG scale
Objective: To create and validate an objective assessing tool to diagnose and monitor HFS and the efficacy of its treatments. Background: Hemifacial spasm (HFS), is…Specific active immunotherapy (SAIT) against alpha-synuclein with AFFITOPE® PD01A and PD03A: Results from the AFF009 phase I trial
Objective: Phase I study with AFFITOPE® PD01A and PD03A to assess safety and tolerability as well as immunogenicity of this approach in MSA patients. Background:…
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