Effect of deep brain stimulation on clinical outcome in Parkinson’s disease patients with different genetic status
Objective: The aim of this study was to evaluate the effect of the genetic status on the clinical outcome of PD patients undergoing DBS. Background:…Resistance to Parkinson’s disease among LRRK2 mutation carriers is associated with higher plasma levels of urate but not its purine precursors
Objective: To determine whether plasma purine concentrations differ between people with Parkinson's disease (PD) and matched controls among carriers of pathogenic mutations in Leucine-Rich Repeat…Nurr1 gene: A new research target for Parkinson’s disease
Objective: The objective of our study is to determine if Nurr1 gene, a transcription factor essential for dopamine (DA) neuron development and survival, is a…Polymorphisms of glutamatergic system genes are associated with levodopa-induced dyskinesia in Parkinson’s disease
Objective: We aimed to study the association between glutamatergic system gene polymorphisms (SLC1A2 – gene, coding excitatory acids transporter, and GRIN2A gene, coding a subunit…Genome-wide association studies of motor and cognitive progression in Parkinson’s disease
Objective: Motor and cognitive progression in Parkinson’s is heterogeneous. Our aim is to identify single nucleotide polymorphisms (SNPs) associated with disease progression. Background: Rare genetic…Daughter’s ataxia reveals father’s genetic Parkinsonism. The first reported case of Spinocerebellar ataxia -15 presenting with levodopa responsive hemi Parkinsonism
Objective: A 38 year old Australian florist of Anglo-Celtic origin described two years of difficulty using his right hand with associated sensory disturbance attributed initially…Substantia Nigra Echogenicity Associated with Clinical Subtypes of Parkinson’s Disease
Objective: We classified Parkinson’s disease (PD) patients into different subtypes and evaluated the correlation between the substantia nigra (SN) echogenicity and disease progression. Background: It…Brain Network Connectivity Measured by Diffusion Tensor Imaging Predicts Prognosis in Parkinson’s Disease
Objective: We aimed to explore whether network connectivity structure as measured by diffusion tensor imaging (DTI) are associated with progression rate of motor and non-motor…Quantification of the PD Motor Syndrome Using an Inclusive Score (PD9) Derived from Sensor Data with Deep Learning
Objective: To quantify the PD motor syndrome with increased temporal and severity granularity using non-invasive internet-of-things (IoT) devices and deep learning methods. Background: Brady-hypokinetic parkinsonistic…Neuromodulation by rTMS in Parkinsons Disease: A fMRI Study
Objective: To compare the efficacy of rTMS [when given at primary motor area (MA), pre-motor area (PMA), supplementary motor area (SMA)] in Patients with Parkinson’s…
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