Neuroprotective effects of antidepressant mirtazapine against dopaminergic neurodegeneration in cultured cells and in parkinsonian mice possibly by targeting astrocytes
Objective: In this study, we examined neuroprotective effects of mirtazapine and involvement of astrocytes in the effects using primary cultured cells and parkinsonian mice. Background:…Effects of dopaminergic medication on executive function in Parkinson’s disease differs according to the clinical stage
Objective: We examined the effect of dopaminergic medication on executive function in 24 drug-naïve PD patients (de novo group) and in 21 PD patients on…Predictor of progressive mild cognitive impairment in patients with Parkinson’s disease.
Objective: To clarify clinical features of patients with progressive mild cognitive impairment patients (MCI) in Parkinson’s disease (PD-MCI). Background: Non-demented PD subjects have MCI and…Subcortical involvement in body and mental action processing: an electrophysiological registration study
Objective: The current research project focusses on the electrophysiological registration of semantics (body versus mental action verbs) within the thalamus, subthalamic nucleus (STN) and the…Motor resonance in Parkinson’s disease: Effects of observed actions on behaviour
Objective: To investigate whether people with Parkinson’s disease (PD) exhibit motor resonance from observed human actions. Background: Seeing another person move can influence one’s own…Consideration of the relationship between severity of Parkinson’s disease and cognitive function, depression, quality of life
Objective: In this study, we aimed to clarify the relationship between PD severity and cognitive function, depression and quality of life. Background: We are continuing…Interval from onset of Parkinson disease to onset of motor and non-motor complications in Leucine-rich repeat kinase 2 (LRRK2) G2019S positive versus matched PD controls
Objective: To compare the latency between onset of Parkinson disease (PD) symptoms and onset of motor and non-motor complications of PD, between G2019S LRRK2 mutation…Genetic analysis of RAB39B mutations in early-onset and familial Parkinson’s Disease in a Taiwanese population.
Objective: To examine the genetic contribution of RAB39B to early-onset and familial PD in a Taiwanese population. Background: Loss of function mutations in RAB39B were…Genetic and pharmacological rescue of DJ-1 loss-of-function caused by a c.192G>C mutation in PARK7
Objective: In this study we investigate the cellular mechanism underlying the Parkinson’s disease (PD)-associated mutation c.192G>C in PARK7 and present a compound treatment that rescues…First Reported Case of Parkinsonism in a Patient with Argininosuccinate Lyase Deficiency
Objective: The purpose of this case report is to detail the phenotype of parkinsonism encountered in a patient with Argininosuccinate Lyase Deficiency (ASLD) that has…
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