Epitope mapping of CSF auto-antibodies to alpha-synuclein
Objective: To identify α-synuclein (α-syn) epitopes bound by endogenous auto-antibodies in CSF from healthy controls (HC) and Parkinson disease (PD) patients. Background: In PD, endogenous…Atypical and slowly progressive FTDP-17 caused by MAPT p.R406W mutations – similarities to AD and PSP.
Objective: We compiled clinical data of a new kindred with the MAPT c.1216C>T (p.Arg406Trp; R406W) mutation and systematically reviewed previously described cases with this mutation.…Congenital mirror movements: When the left hand doesn’t know what the right is doing
Objective: To report on two non-related cases of congenital mirror movements (CMM). Background: Mirror movements (MM) are involuntary symmetrical movements of one side of the body that mirror intentional movements of the…Gait analysis as a complementary tool in the levodopa dose decision in Vascular Parkinson’s Disease
Objective: Evaluate the role of objective gait analysis in the decision of levodopa dose in VPD, in particular when compared to clinical assessment. Background: Vascular…Validation of actigraphy-derived sleep metrics in Parkinson’s disease (PD) patients and elderly controls, taking into account clinical and physiological status
Objective: To developed a novel sleep quantification method using raw actigraphy data from well characterized PD subjects and elderly controls with overnight PSG and home…Low frequency Deep Brain stimulation for Parkinson’s disease – Effect on freezing of gait.
Objective: Parkinson's disease patients who have undergone deep brain stimulation ( DBS) having freezing of gait do not show improvement with high frequency stimulation (…Closed Loop STN DBS for Tremor in Parkinson’s disease using a Neural or Kinematic Signal
Objective: Compare safety, tolerability, efficiency and efficacy of closed loop DBS (clDBS) of the subthalamic nucleus (STN) for resting tremor in Parkinson’s disease (PD) using…Fibroblasts Implanted in Internal Pallidum of Parkinsonian Macaques Exert L-Dopa-Sparing Activity
Objective: To assess the effects of autologous implantation of fibroblasts in the internal globus pallidus of dyskinetic MPTP-lesioned monkeys upon motor behaviour and L-DOPA response.…Parkinson Syndrome associated with inositol-1,4,5-triphosphate receptor antigen type 1 (ITPR1) antibodies
Objective: To illustrate an unusual clinical presentation of Parkinson´s disease (PD) that was effectively treated with immune adsorption. Background: Autoimmune mediated movement disorders may be…Psychiatric comorbidities are common in patients with Orthostatic Tremor
Objective: The objective of this study was to determine if there is a higher prevalence of psychiatric comorbidities, especially anxiety disorders, in orthostatic tremor (OT)…
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