Exploratory Clinical study of role of cerebral dopamine neurotrophic factor (CDNF) mediating endoplasmic reticulum stress (ERS) in Parkinson Disease
Objective: 1: to identify and measure endogenous CDNF levels in peripheral whole blood of healthy control subjects and to examine CNDF expression development profile across the life…Alpha-synucleinopathy and mitochondrial dysfunction in a cell based model of neurodegeneration: Implications in the pathogenesis of sporadic Parkinson’s disease
Objective: To elucidate the role of α-synuclein, parkin and mitochondria in a cell-based model of neurodegeneration relevant to Parkinson's disease pathogenesis. Background: The suggested mechanisms…Exposure to bifenthrin contributes to Parkinson’s disease in mouse model
Objective: To explore the relationship between pyrethroid bifenthrin and Parkinson’s disease on mouse model. Background: Pyrethroid is now widely used on account of its high…Epitope mapping of CSF auto-antibodies to alpha-synuclein
Objective: To identify α-synuclein (α-syn) epitopes bound by endogenous auto-antibodies in CSF from healthy controls (HC) and Parkinson disease (PD) patients. Background: In PD, endogenous…Atypical and slowly progressive FTDP-17 caused by MAPT p.R406W mutations – similarities to AD and PSP.
Objective: We compiled clinical data of a new kindred with the MAPT c.1216C>T (p.Arg406Trp; R406W) mutation and systematically reviewed previously described cases with this mutation.…Congenital mirror movements: When the left hand doesn’t know what the right is doing
Objective: To report on two non-related cases of congenital mirror movements (CMM). Background: Mirror movements (MM) are involuntary symmetrical movements of one side of the body that mirror intentional movements of the…Gait analysis as a complementary tool in the levodopa dose decision in Vascular Parkinson’s Disease
Objective: Evaluate the role of objective gait analysis in the decision of levodopa dose in VPD, in particular when compared to clinical assessment. Background: Vascular…Validation of actigraphy-derived sleep metrics in Parkinson’s disease (PD) patients and elderly controls, taking into account clinical and physiological status
Objective: To developed a novel sleep quantification method using raw actigraphy data from well characterized PD subjects and elderly controls with overnight PSG and home…Low frequency Deep Brain stimulation for Parkinson’s disease – Effect on freezing of gait.
Objective: Parkinson's disease patients who have undergone deep brain stimulation ( DBS) having freezing of gait do not show improvement with high frequency stimulation (…Closed Loop STN DBS for Tremor in Parkinson’s disease using a Neural or Kinematic Signal
Objective: Compare safety, tolerability, efficiency and efficacy of closed loop DBS (clDBS) of the subthalamic nucleus (STN) for resting tremor in Parkinson’s disease (PD) using…
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