Targeting alpha-Synuclein Aggregation for the Treatment of Parkinson’s Disease
Objective: To develop small molecular weight compounds (SMEs) as disease-modifying agents, which are designed to arrest or even reverse the aggregation process of alpha-synuclein (aSyn)…Intranasal delivery of insulin for the restoration of memory signaling in Alzheimer disease
Objective: Objective of this study is to develop delivery-system to overcome BBB by employing novel, non-invasive approach via nasal route. The olfactory neural pathway provides…Gray Matter Density in Essential Tremor: A Lobule by Lobule Analysis of the Cerebellum
Objective: Our hypothesis was that regional differences in cerebellar gray matter (GM) density may better distinguish essential tremor (ET) cases from controls. Background: The pathophysiological…Tremor in motorneuron disease: central or peripheral origin?
Objective: To investigate whether postural/action tremor in motorneuron disease (MND) has a central origin. Background: MND refers to the whole spectrum of progressive degenerative diseases…Effect of Virtual Reality on Balance Rehabilitation
Objective: To verify the effect of a balance rehabilitation program with virtual reality (VR) in patients with SCA Background: Spinocerebellar ataxias (SCAs) constitute a group…Is the cerebellum a good target for neuromodulation in movement disorders?
Objective: To assess the effects of dentate nucleus transcranial magnetic stimulation and deep brain stimulation on patients with cerebellar ataxia of different etiologies. Background: Cerebellar…Relationship between sensory augmentation and exercise routine in the improvement in balance and gait in a patient with lithium-induced ataxia
Objective: This case report describes the use of sensory augmentation and an exercise routine to improve balance and gait in a patient with lithium-induced ataxia.…Fentanyl Induced Chorea: A Case Report
Objective: To report the acute onset of generalized chorea as an adverse reaction to transdermal fentanyl Background: Chorea can present with degenerative conditions or in an…Cholinergic activity, mobility, and attention in mild cognitive impairment
Objective: The aim of this investigation is to relate cholinergic activity (CA) to objective measures of balance, gait, and attention in a MCI and control…Axial Myoclonus in a Patient with PSP
Objective: This is a case report from the Portland VA Medical Center. Background: PSP is a parkinsonian neurodegenerative disorder characterized by deposition of tau in…
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