Motor effects induced by D1- or D2-like receptor agonists in experimental parkinsonism.
Objective: We set out to compare movement patterns induced by systemic administration of l-dopa versus D1- or D2-class DA receptor agonists in mice with unilateral…Altered somtatosensory cortex neuronal activity in a rat model of Parkinson`s disease and levodopa-induced dyskinesias
Objective: In this study, we explored the neuronal firing activity of excitatory pyramidal cells and inhibitory interneurons in the forelimb region of the primary somatosensory…Serum lipid profile in Parkinsons disease patients from Southern Spain
Objective: Our first aim was to evaluate differences in the blood lipid profile levels between Parkinsons disease (PD) patients and healthy controls (HC). Secondly, in…Phosphodiesterases and striatal pathways in Parkinson’s disease
Objective: To use phosphodiesterase (PDE)10A ([11C]IMA107) and PDE4 ([11C]Rolipram) positron emission tomography (PET) molecular imaging combined with diffusion tensor imaging (DTI) based probabilistic tractography to explore the expression…Plasma Biomarkers in Idiopathic Normal Pressure Hydrocephalus
Objective: (1) To investigate the role of plasma biomarkers that is known to related to Alzheimer’s disease in INPH(2) To assess the diagnostic and prognostic…Deferiprone combined with phlebotomy for aceruloplasminemia
Objective: To evaluate the efficacy and safety of chelation therapy with deferiprone combined with phlebotomy in reducing iron stores and neurological progression in aceruloplasminemia. Background:…Perceptual decision making and reflection impulsivity in drug naïve and treated patients with restless legs syndrome
Objective: To investigate perceptual decision making and reflexion impulsivity in patients with restless legs syndrome (RLS) with and without dopamine replacement therapy. Background: Detailed neuropsychological…Wearable motion quantification and electronic diaries for long-term monitoring of Parkinson’s disease
Objective: To clinically assess wearable motion sensors for measuring tremor, dyskinesia, slowness, and mobility and an electronic diary for Parkinson’s disease (PD) Background: A patient…Efficacy of Smartphone-enabled Active Tests in Automated PD Severity Assessment
Objective: To compare the efficacy of five smartphone-enabled active tests in detecting severity changes after medication, via an automated Parkinson Disease Severity Score (PDSS). Background:…Effects of non-invasive electrical and magnetic stimulation to improve motor and cognitive function in Parkinson’s disease: a meta-analytical review
Objective: This meta-analytical review aims to compare 1) the effects of non-invasive repetitive transcranial magnetic (rTMS) and transcranial electrical stimulation (tES); and 2) identify optimal…
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