Injection guidance use in the management of cervical dystonia with botulinum toxin
Objective: Investigate the use of injection guidance techniques and their impact on patient outcomes in the routine management of cervical dystonia (CD) with botulinum neurotoxin…Multiple Neural Networks dysfunction in Primary Blepharospasm: An Independent Components Analysis Study
Objective: This study aimed to explore altered functional brain connectivity and the possible correlations of these networks with clinical variables in BPS. Background: Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary blinking and eyelid spasms. The pathophysiology of BPS remains unclear. Methods: Twenty-five patients with BPS and 25 age-and gender-matched healthy controls received resting-state fMRI scan. Group ICA was performed with the GIFT toolbox. Results: (1) There were no significant differences in the demographic variables between two groups besides the HAMA scores [table 1]. (2) Comparing with healthy control group, BPS patients exhibited different resting-state connections within sensory-motor network (SMN), right frontoparietal network (rFPN) and salience network (SN) [figure 1, figure 2]. BPS patients exhibited decreased connectivity within SMN that involved regions of the bilateral primary sensorimotor cortex, supplementary motor area, right superior frontal gyrus (BA 6), bilateral precuneus and left superior parietal cortex [table 2]. Within rFPN, decreased connections were observed in the middle frontal gyrus, DLPFC and inferior frontal gyrus [table 3]. Regarding salience network, increased connectivity was observed in the left superior frontal gyrus and middle frontal gyrus (including the DLPFC) [table 4]. We found positive correlation between the left superior frontal gyrus and HAMA scores, but this result was not significant. (3) Among the BPS patients, 12 performed sensory tricks positive (ST+), 9 perform sensory tricks negative (ST-). ST+ as compared to ST- patients exhibited significant higher connectivity in right premotor cortex within SMN [figure 3, table 5]. The results also showed a significant negative correlation between the right superior frontal gyrus and disease duration (Pearson's correlation r = -0.414, p = 0.038)[figure 4]. (4) We compared the SMN connectivity maps from pre- and after- treatment of 6 patients, but found no significant result. Conclusions: Multiple neural networks dysfunction may play roles in BPS.A Comparison of Temporal Discrimination Thresholds in Musicians with and without Dystonia
Objective: To compare the Temporal Discrimination Thresholds (TDT) of Musician’s Dystonia (MD) patients with those of healthy control musicians. Background: The TDT is a measure…Effect of Valproic Acid on Dystonia in a patient with Traumatic Brain Injury: a case report.
Objective: Valproic Acid, a branched short chain fatty acid, is widely used as an epileptic drug and mood stabilizer [1]. Its mechanism of action is…Clinical Criteria for Subtyping Parkinson’s Disease: Differences in imaging and CSF biomarkers and longitudinal progression
Objective: To introduce a new practical classification method to assign individuals with Parkinson’s disease (PD) into distinct subtypes using baseline dataset, then to compare neuroimaging,…The combination of clinical scales and walking measures to predict falls in Parkinson’s disease: Does the length of the prospective follow-up period matter?
Objective: This study aimed: (i) to identify the best combination of clinical scales and walking measures to predict falls in people with Parkinson’s disease (PD)…Developing a guide to facilitate involving people with Parkinson’s and their carers in service improvement
Objective: To develop an easy-to-use guide for service development project leads and patients/carers to facilitate the involvement of the latter in the development and implementation…Vascular hemiballismus due to a lentiform nucleus infarct
Objective: The aim of this study is to present a case of right hemiballism due to an ischemia located in the left lentiform nucleus. Background:…Istradefylline for daytime sleepiness and sleep disturbances in patients with Parkinson’s disease: an open-label, 3-month study
Objective: To evaluate the effect of istradefylline on daytime sleepiness and sleep disturbances as well as motor symptoms in patients with Parkinson’s disease (PD) in…Long-Term Dopamine Transporter Imaging and Clinical Effects of the Mixed-Lineage Kinase Inhibitor CEP-1347 in the PRECEPT Parkinson Trial
Objective: To assess the imaging and clinical effects of CEP-1347 after treatment discontinuation in the Parkinson Research Examination of CEP-1347 Trial (PRECEPT), a multi-center randomized…
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