Predictive Ability of Clinical Timed Tests for Postural Instability and Gait Difficulty in Parkinson’s Disease
Objective: To identify clinical determinants for postural instability and gait difficulty in persons with Parkinson's disease (PD). Background: Gait deficits and postural instability in persons…Sports or no sports – is that the question in PD?
Objective: A multitude of risk factors or protective factors in developing Parkinson’s Disease (PD) are under discussion, as caffeine consumption or smoking .. Background: Frequent physical activity…Is There a Correlation Between Functional Capacity Upper Limbs and Falls Risk and Postural Instability in Parkinson’s Disease?
Objective: The goal of this study was to verify by a Brief Battery Functional Assessment (BBFA) the correlation between upper limb function skills with falls…The Adult Spasticity International Registry (ASPIRE) Study: Treatment Utilization Patterns in Patients Treated for Both Upper and Lower Limb Spasticity
Objective: To examine the treatment patterns of onabotulinumtoxinA utilization in patients treated for upper and lower limb spasticity, in combination, from the ASPIRE study (1…Tourettism associated with the Xq25 Microduplication Syndrome
Objective: To present a novel case of Tourettism emerging within the Xq25 microduplication syndrome. Background: Tourette syndrome (TS) is a childhood-onset neurobehavioral disorder hallmarked by…Postural control is maintained after a 8-months period of exercise in people with Parkinson’s disease
Objective: Our aim was to investigate the effects of different long-lasting exercises programs on the postural control in people with Parkinson’s disease (PD). Background: Postural…Injection guidance use in the management of cervical dystonia with botulinum toxin
Objective: Investigate the use of injection guidance techniques and their impact on patient outcomes in the routine management of cervical dystonia (CD) with botulinum neurotoxin…Multiple Neural Networks dysfunction in Primary Blepharospasm: An Independent Components Analysis Study
Objective: This study aimed to explore altered functional brain connectivity and the possible correlations of these networks with clinical variables in BPS. Background: Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary blinking and eyelid spasms. The pathophysiology of BPS remains unclear. Methods: Twenty-five patients with BPS and 25 age-and gender-matched healthy controls received resting-state fMRI scan. Group ICA was performed with the GIFT toolbox. Results: (1) There were no significant differences in the demographic variables between two groups besides the HAMA scores [table 1]. (2) Comparing with healthy control group, BPS patients exhibited different resting-state connections within sensory-motor network (SMN), right frontoparietal network (rFPN) and salience network (SN) [figure 1, figure 2]. BPS patients exhibited decreased connectivity within SMN that involved regions of the bilateral primary sensorimotor cortex, supplementary motor area, right superior frontal gyrus (BA 6), bilateral precuneus and left superior parietal cortex [table 2]. Within rFPN, decreased connections were observed in the middle frontal gyrus, DLPFC and inferior frontal gyrus [table 3]. Regarding salience network, increased connectivity was observed in the left superior frontal gyrus and middle frontal gyrus (including the DLPFC) [table 4]. We found positive correlation between the left superior frontal gyrus and HAMA scores, but this result was not significant. (3) Among the BPS patients, 12 performed sensory tricks positive (ST+), 9 perform sensory tricks negative (ST-). ST+ as compared to ST- patients exhibited significant higher connectivity in right premotor cortex within SMN [figure 3, table 5]. The results also showed a significant negative correlation between the right superior frontal gyrus and disease duration (Pearson's correlation r = -0.414, p = 0.038)[figure 4]. (4) We compared the SMN connectivity maps from pre- and after- treatment of 6 patients, but found no significant result. Conclusions: Multiple neural networks dysfunction may play roles in BPS.A Comparison of Temporal Discrimination Thresholds in Musicians with and without Dystonia
Objective: To compare the Temporal Discrimination Thresholds (TDT) of Musician’s Dystonia (MD) patients with those of healthy control musicians. Background: The TDT is a measure…Effect of Valproic Acid on Dystonia in a patient with Traumatic Brain Injury: a case report.
Objective: Valproic Acid, a branched short chain fatty acid, is widely used as an epileptic drug and mood stabilizer [1]. Its mechanism of action is…
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