Imaging of phosphodiesterase 10 A (PDE10A) enzyme levels in the living human brain of Huntington’s disease gene expansion carriers and healthy controls with positron emission tomography.
Objective: The objective of this study was to examine the loss of Phosphodiesterase 10A enzyme (PDE10A) across a broad spectrum of Huntington’s disease (HD) stages.…Depression among Inpatients with Huntington’s Disease: Patient Characteristics and Outcomes
Objective: To better understand the relationship between Huntington’s Disease and depression. Background: Huntington’s Disease (HD) is an uncommon genetic neurodegenerative disorder in the United States…The nature of postural tremor in Parkinson’s disease
Objective: To identify dopaminergic mechanisms underlying postural tremor in Parkinson's disease. Background: Parkinson’s tremor classically occurs at rest, but many patients also have a postural…Characterizing the Bcl-2 Associated Athanogene 5 Interactome
Objective: Characterizing the Bcl-2 Associated Athanogene 5 (BAG5) interactome will uncover the molecular pathways with which BAG5 associates and further elucidate its role in dopaminergic…Motor effects induced by D1- or D2-like receptor agonists in experimental parkinsonism.
Objective: We set out to compare movement patterns induced by systemic administration of l-dopa versus D1- or D2-class DA receptor agonists in mice with unilateral…Altered somtatosensory cortex neuronal activity in a rat model of Parkinson`s disease and levodopa-induced dyskinesias
Objective: In this study, we explored the neuronal firing activity of excitatory pyramidal cells and inhibitory interneurons in the forelimb region of the primary somatosensory…Serum lipid profile in Parkinsons disease patients from Southern Spain
Objective: Our first aim was to evaluate differences in the blood lipid profile levels between Parkinsons disease (PD) patients and healthy controls (HC). Secondly, in…Phosphodiesterases and striatal pathways in Parkinson’s disease
Objective: To use phosphodiesterase (PDE)10A ([11C]IMA107) and PDE4 ([11C]Rolipram) positron emission tomography (PET) molecular imaging combined with diffusion tensor imaging (DTI) based probabilistic tractography to explore the expression…Plasma Biomarkers in Idiopathic Normal Pressure Hydrocephalus
Objective: (1) To investigate the role of plasma biomarkers that is known to related to Alzheimer’s disease in INPH(2) To assess the diagnostic and prognostic…Deferiprone combined with phlebotomy for aceruloplasminemia
Objective: To evaluate the efficacy and safety of chelation therapy with deferiprone combined with phlebotomy in reducing iron stores and neurological progression in aceruloplasminemia. Background:…
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