Efficacy of Smartphone-enabled Active Tests in Automated PD Severity Assessment
Objective: To compare the efficacy of five smartphone-enabled active tests in detecting severity changes after medication, via an automated Parkinson Disease Severity Score (PDSS). Background:…Effects of non-invasive electrical and magnetic stimulation to improve motor and cognitive function in Parkinson’s disease: a meta-analytical review
Objective: This meta-analytical review aims to compare 1) the effects of non-invasive repetitive transcranial magnetic (rTMS) and transcranial electrical stimulation (tES); and 2) identify optimal…Design of a randomized, sham-controlled trial of pallidal neurostimulation versus botulinum toxin treatment for cervical dystonia (StimTox-CD)
Objective: In this trial we will assess the efficacy and safety of pallidal deep brain stimulation (DBS) versus botulinum toxin A (BoNT A) therapy in cervical…Focused ultrasound subthalatomy restores intracortical inhibition in PD
Objective: To test the effects of focused ultrasound subthalatomy on motor cortex excitability in Parkinson’s disease (PD). Background: Short-interval intracortical inhibition (SICI), a GABAAR-mediated inhibition…Ultrasonography-guided Botulinum Toxin Type-A Injection in Tremor. An open-label Study
Objective: To assess the role of ultrasound-guided (US) Onabotulinumtoxin-A (BoNT-A) injections for various types of hand and head tremor. Background: Focal treatment of head and…Tremor Characteristics in Essential Tremor and Dystonic Tremor
Objective: To explore the characteristics of tremor in patients with ET and DT by using neurophysiologic measures. Background: Tremor features in patients with essential tremor…Neurotological Findings in Sporadic Ataxia
Objective: To examine vestibular disorders in patients with sporadic ataxia (SA). Background: Ataxias are a heterogeneous group of neurodegenerative diseases characterized by the presence of…Early diagnosis in Spinocerebellar Ataxias: Prospects for clinical alterations and ethical dilemmas during preclinical trials.
Objective: To assess the acceptation level and ethical concerns for participating in early intervention approaches in Spinocerebellar Ataxia type 2 preclinical carriers and to evaluate…A case report: a primary progressive multiple sclerosis (PPMS) with adolescent-onset of progressive cerebellar ataxia
Objective: To report a 26 year-old female with progressive cerebellar ataxia for 12 years diagnosed to have primary progressive multiple sclerosis (PPMS). Background: Multiple sclerosis (MS) is a kind of CNS demyelinating disease. About 15% MS patients have a progressive course without a relapsing course. These patients are considered to have PPMS. It often presented a progressive neurological problem--such as lateralizing weakness, or numbness in the legs. Cerebellar ataxia as primary symptom is less frequent in PPMS and it's usually diagnosed in their 40-60 years at age. Here we present a case with adolescent-onset PPMS presenting progressive cerebellar ataxic syndrome. Methods: A 26 year-old female Taiwanese presented with 12 years of progressive ataxic gait. She denied relapses and remissions of symptoms. There were no mental decline, involuntary movements, muscle hypertrophy or abnormality in hearing or vision. She had no associated family history or consanguineous parents. Physical examination revealed dysarthria, dysmetria/intentional tremor and dysdiadochokinesia in four limbs and bilateral extensor plantar response. In addition, she had normal tendon reflexes, intact sensory function and negative Romberg test without parkinsonian features. Her gait was wide-based. Results: On investigation, CBC, lipid profile, LFT, chest X-ray, serum electrolytes, ECG, EEG and NCV showed normal results. VEP study were abnormal. The brain and cervical spine MRI showed no significant cerebellar atrophy or myelopathy. Instead, FLAIR-weighted imaging showed diffuse plaques in brainstem and cerebral white matters with a predilection for periventricular white matter with the major axes perpendicular to the ventricular surface (Dawson’s fingers). Besides, the CSF study revealed oligoclonal banding and elevation of IgG index. She had normal serum copper and ceruloplasmin levels and plasma very long-chain fatty acids (VLCFA) analysis. The genetic testing for spinocerebellar ataxia ( SCA1, 2, 3, 6, 7 and 17) is negative. In view of progressive ataxia with diffuse white matter lesions, a diagnosis of PPMS was made. Conclusions: PPMS can be a etiology in adolescent patient with progressive ataxic syndrome. Brain MRI is a better tool for detecting cerebral white matter lesions compared to CT in differential diagnosis of progressive ataxia. References:…Generalized choreodystonia in a patient with HIV and hepatitis C with the history of opioid drug abuse after treating with interferon- 2alpha (Peginton)
Objective: We reported a case of a patient G., 47 years old treated with Pegintron (1,5 mcg/kg/week) and ribavirin (15 mg/kg/day) within a year due…
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