The novel COMT-inhibitor ODM-104 and optimized carbidopa in combination with modified release levodopa reduce levodopa fluctuation and increase minimum concentrations in healthy subjects, when compared to the standard carbidopa/levodopa/entacapone combination
Objective: To evaluate the plasma pharmacokinetics (PK) of orally administered modified release (MR) levodopa in combination with the aromatic L-amino acid decarboxylase inhibitor carbidopa and…Therapy escalation in Parkinson’s disease – The TEMP trial, a regional survey
Objective: To assess socio-demographic and disease specific data in patients with Parkinson's disease (PD) before and one year after therapy escalation with subcutaneous apomorphine (APO),…Safety and efficacy of pardoprunox for patients with Parkinson’s disease: A meta-analysis
Objective: The aim of this meta-analysis is to synthesize evidence from published randomized controlled trials (RCTs) about the safety and efficacy of Pardoprunox for Patients…Levodopa-carbidopa intestinal gel in routine care of advanced Parkinson’s disease patients: Final long-term efficacy results on motor complications from the GLORIA registry
Objective: To evaluate the effect of levodopa-carbidopa intestinal gel (LCIG, designated in the United States as carbidopa-levodopa enteral suspension) on motor fluctuations and dyskinesia in…The influence of cerebellar transcranial direct current stimulation on skill acquisition in Parkinson’s disease
Objective: The purpose was to determine the influence of cerebellar transcranial direct current stimulation (c-tDCS) on motor skill acquisition in Parkinson's disease (PD). Background: c-tDCS…DIRECT DBS: A prospective, multi-center clinical trial with blinding for a directional DBS lead
Objective: DIRECT DBS is an exploratory study which will investigate the effects of subthalamic deep brain stimulation (DBS) using directional DBS leads with current steering…Mobile decision support system for nurse managment of deep brain stimulation
Objective: To decrease time spent on deep brain stimulation (DBS) programming while improving quality of life for patients and caregivers by providing nurses with an…Effects of pyridostigmine bromide vs. fludrocortison in the treatment of orthostatic hypotension in Parkinson’s disease
Objective: To report results of an investigator-initiated trial to show the non-inferiority of pyridostigmine bromide (PB) vs. fludrocortisone (FC) in the treatment of symptomatic orthostatic…Familial cortical myoclonic tremor with epilepsy in Chinese population: Clinical and neurophysiologic features in nine pedigrees from People’s Republic of China
Objective: To delineate and analyze the clinical and neurophysiologic features of 55 patients from nine Chinese familial cortical myoclonic tremor with epilepsy (FCMTE) pedigrees. Background:…The effects of intensive speech treatment on intelligibility in Spanish dysarthria secondary to Parkinson’s disease
Objective: To examine the effects of intensive speech treatment (LSVT-LOUD; Ramig et al., 2001) on intelligibility at conversational level in Spanish dysarthria secondary to Parkinson's…
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