The epigenetic regulation of HIF-1α by SIRT1 in MPP+ treated SH-SY5Y cells
Objective: Both silent information regulator 1 (SIRT1) and hypoxia inducible factor 1 (HIF-1) have been found to play important roles in the pathophysiology of Parkinson's…Role of macroautophagy in regulating microglia-mediated neuroinflammation and dopaminergic neuron injury
Objective: To investigate the potential role of macroautophagy in the regulation of microglia-mediated neuroinflammation and dopamine neuron injury. Background: Chronic neuroinflammation, a process mediated by…Piper longum L. alkaloids inhibit lipopolysaccharide-stimulated microglial activation and protect nigral dopaminergic neurons
Objective: The ethanol-extracted alkaloids from the dry seeds of Piper longum L. (PLL) (family Piperaceae) PLA contain numerous compounds. We evaluate the potential of PLA…Diffusion tensor imaging biomarkers of nigrostriatal neurodegeneration in early Parkinson’s disease
Objective: Identify magnetic resonance imaging (MRI) biomarkers of nigrostriatal neurodegeneration in early-stage drug-naïve Parkinson's disease (PD). Background: Diffusion tensor imaging (DTI) is an MRI technique…Long term recordings of subthalamic ocillatory activity in patients with Parkinson’s disease
Objective: The aim of this study was to investigate the stability of beta oscillations (13 - 30 Hz) in the subthalamic nucleus (STN) of patients…Circadian dysfunction in Parkinson’s disease: Effects on impaired gait initiation and locomotion
Objective: To investigate the impact of circadian rhythm (CR) and time of the day on the magnitude of motor impairments during gait initiation and continuation…Cyclic glycine-proline increased in the cerebrospinal fluid of Parkinson’s patients after supplementation of blackcurrant anthocyanins: Potential biomarker for treatment
Objective: We evaluated the changes of insulin-like growth factor-1 bioavailability in the Parkinson's disease patients after 28 day supplementation of blackcurrant anthocyanin. Background: Elevated insulin-like…Propranolol therapy for tardive dyskinesia: A retrospective examination
Objective: To examine the tolerability and effectiveness of propranolol in treating tardive dyskinesia (TD). Background: TD is a disabling, often irreversible, movement disorder that results…Lance-Adams syndrome with post-hypoxic myoclonus- physiotherapy intervention
Objective: To evaluate the benefit of physiotherapy (PT) interventions on functional limitations in a patient with Lance-Adams Syndrome (LAS) with post-hypoxic myoclonus using 10 meter…The spectrum of CNS hyperexcitability in gluten-related disorders
Objective: To describe the clinical and neurophysiological spectrum of CNS hyperexcitability in Gluten-Related Disorders. Background: Gluten-related disorders (GRD) represent a spectrum of diverse manifestations sharing…
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