Coding and non-coding glucocerebrosidase variants have an impact on cognitive decline in Parkinson’s disease
Objective: To evaluate the impact of genetic variants in the Glucocerebrosidase gene (GBA) on cognitive impairment in a large cohort of Parkinson's disease (PD) patients…Paroxysmal exercise-induced dystonia within the phenotypic spectrum of ECHS1 deficiency
Objective: To describe a family with two siblings affected by different dystonic disorders as a resulting phenotype of ECHS1 mutations. Background: ECHS1 encodes a mitochondrial…Generation of human induced pluripotent stem cells carrying a safety bet for cell-based therapy in Parkinson’s disease
Objective: To increase the safety of future cell-based therapy in Parkinson's disease, we generated human induced pluripotent stem cells (hiPSCs) possessing a safety switch via…Sonographic investigation of Pisa syndrome in Parkinson’s disease
Objective: We hypothesized that the trunk muscles might have an impact on Pisa syndrome, so we performed a sonographic investigation of the trunk muscles of…Physical training prevents depressive-like behavior and bdnf decrease in an animal model of Parkinson’s disease
Objective: The aim of this study was to investigate the effects of two types of physical training on depressive-like behavior and pro-BDNF, BDNF and its…Glatiramir acetate (Copaxone) causes restoration of the striatal dopamine in a progressive MPTP mouse model of Parkinson’s disease
Objective: To assess if a microglial modulator, Glatiramer Acetate (GA), can restore loss of striatal dopamine (DA) and behavioral deficits following progressive 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)…Dissecting the molecular mechanisms of Fyn-mediated levodopa induced dyskinesias
Objective: To investigate the crosstalk between D1 receptor (D1R) and the signaling of Fyn protein kinase in a mice model of levodopa (L-DOPA) induced dyskinesias…Constipation in early de novo Parkinson’s disease: Prevalence and correlates with clinical features, imaging and non-imaging biomarkers
Objective: To explore the association between constipation and clinical features, imaging and non-imaging biomarkers in early de novo (untreated) Parkinson's disease (PD) patients. Background: Constipation…Floor square size predicts step count of 360° turns in PD patients with freezing
Objective: To determine the effect of floor square size on turning behavior in patients with PD. Background: Turning has been repeatedly shown to be the…Gender-age features of autonomic heart rhythm disturbances in Parkinson’s disease patients
Objective: To determine the gender differences and age-dependent features of autonomic heart rhythm disturbances in patients with Parkinson's disease (PD). Background: Autonomic heart rate failures…
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