Influence of different spike sorting algorithms on the detection of single unit spiking activity in the subthalamic nucleus of patients with Parkinson’s disease
Objective: To determine the most suitable spike sorting algorithm for intraoperatively recorded extracellular currents in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD).…Dopamine and task-dependent evolution of oscillatory activity in the subthalamic nucleus (STN) and coupling between the STN local field potential and muscle activity in Parkinson’s disease
Objective: To investigate how subthalamic nucleus local field potentials (STN-LFP) and coupling between STN-LFP and electromyogram (EMG) in static and phasic movements are modulated by…Heart rate variability to differentiate dementia with Lewy bodies from Alzheimer’s disease in patients with mild cognitive impairment
Objective: We aimed to determine whether heart rate variability (HRV) can aid in the differentiation of DLB from AD at the MCI stage. Background: Mild…Modeling dementia with Lewy bodies using patient-derived neurons
Objective: To model Dementia with Lewy bodies (DLB) using neurons derived from patients clinically diagnosed with the disease. Background: A major challenge in neurodegenerative disease…Catechol-o-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinson’s disease
Objective: The Catechol-O-Methyltransferase (COMT) Val158Met polymorphism has been proposed to be associated with increased risk of PD and have a specific impact on dopamine-mediated prefrontal…Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson’s disease
Objective: To investigate the role of APOE, MAPT, COMT, SNCA and GBA genes in both striatal dopaminergic denervation and the development of dementia in Parkinson's…Occurrence and pattern of cognitive deficits in prodromal Parkinson’s disease
Objective: To assess a possible cognitive impairment and its specific profile in the prodromal phase of Parkinson's disease (PD). Background: Cognitive impairment is common in…Monoaminergic biomarkers of cognitive decline in Parkinson’s disease and Lewy body dementia
Objective: The objective of this study was the identification of biochemical markers of cognitive impairment in Parkinson's disease (PD) and dementia with Lewy bodies (DLB)…Impulsive action tendencies in GPi DBS Parkinson’s patients
Objective: To test the effects of GPi DBS on susceptibility to impulsive action errors and the proficiency of reactive inhibitory control to counteract interference from…The alterations in behavioral memory for prolongation disease duration in patients with Parkinson’s disease
Objective: Aim of this study is to assess the alterations in daily behavioral memory for prolongation of disease duration in PD. Background: We are continuing…
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